3bi4: Difference between revisions

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[[Image:3bi4.jpg|left|200px]]


{{Structure
==Crystal structures of fms1 in complex with its inhibitors==
|PDB= 3bi4 |SIZE=350|CAPTION= <scene name='initialview01'>3bi4</scene>, resolution 2.200&Aring;
<StructureSection load='3bi4' size='340' side='right'caption='[[3bi4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=298:N-[(1E,2Z)-BUT-2-EN-1-YLIDENE]-N&#39;-[(2E)-BUT-2-EN-1-YLIDENE]BUTANE-1,4-DIAMINE'>298</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
<table><tr><td colspan='2'>[[3bi4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BI4 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyamine_oxidase Polyamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.3.11 1.5.3.11] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= Fms1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=298:N-[(1E,2Z)-BUT-2-EN-1-YLIDENE]-N-[(2E)-BUT-2-EN-1-YLIDENE]BUTANE-1,4-DIAMINE'>298</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bi4 OCA], [https://pdbe.org/3bi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bi4 RCSB], [https://www.ebi.ac.uk/pdbsum/3bi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bi4 ProSAT]</span></td></tr>
|RELATEDENTRY=[[3bi2|3BI2]], [[3bi5|3BI5]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bi4 OCA], [http://www.ebi.ac.uk/pdbsum/3bi4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bi4 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/FMS1_YEAST FMS1_YEAST] Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance.<ref>PMID:12670477</ref> <ref>PMID:14617780</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bi4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bi4 ConSurf].
<div style="clear:both"></div>


'''Crystal structures of fms1 in complex with its inhibitors'''
==See Also==
 
*[[Polyamine oxidase|Polyamine oxidase]]
 
== References ==
==About this Structure==
<references/>
3BI4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BI4 OCA].
__TOC__
[[Category: Polyamine oxidase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Hao Q]]
[[Category: Hao, Q.]]
[[Category: Huang Q]]
[[Category: Huang, Q.]]
[[Category: enzyme-inhibitor complex]]
[[Category: oxidoreductase]]
[[Category: polyamine oxidase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:26:33 2008''

Latest revision as of 11:48, 30 October 2024

Crystal structures of fms1 in complex with its inhibitorsCrystal structures of fms1 in complex with its inhibitors

Structural highlights

3bi4 is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FMS1_YEAST Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Landry J, Sternglanz R. Yeast Fms1 is a FAD-utilizing polyamine oxidase. Biochem Biophys Res Commun. 2003 Apr 11;303(3):771-6. PMID:12670477
  2. ↑ Chattopadhyay MK, Tabor CW, Tabor H. Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13869-74. Epub 2003 Nov 14. PMID:14617780 doi:http://dx.doi.org/10.1073/pnas.1835918100

3bi4, resolution 2.20Å

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