2vi6: Difference between revisions

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-==CRYSTAL STRUCTURE OF THE NANOG HOMEODOMAIN==
-<StructureSection load='2vi6' size='340' side='right' caption='[[2vi6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+==Crystal Structure of the Nanog Homeodomain==
+<StructureSection load='2vi6' size='340' side='right'caption='[[2vi6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vi6]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VI6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vi6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VI6 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vi6 OCA], [http://pdbe.org/2vi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vi6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vi6 PDBsum]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vi6 OCA], [https://pdbe.org/2vi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vi6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vi6 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NANOG_MOUSE NANOG_MOUSE] Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed:25825768). Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (By similarity). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.[UniProtKB:Q9H9S0]<ref>PMID:12787504</ref> <ref>PMID:12787505</ref> <ref>PMID:14728807</ref> <ref>PMID:15502159</ref> <ref>PMID:16518401</ref> <ref>PMID:16791199</ref> <ref>PMID:16801560</ref> <ref>PMID:21915945</ref> <ref>PMID:22988117</ref> <ref>PMID:25825768</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2vi6_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2vi6_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 28: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: Jauch, R]]
+[[Category: Mus musculus]]
-[[Category: Kolatkar, P R]]
+[[Category: Jauch R]]
-[[Category: Ng, C K.L]]
+[[Category: Kolatkar PR]]
-[[Category: Saitakendu, K S]]
+[[Category: Ng CKL]]
-[[Category: Stevens, R C]]
+[[Category: Saitakendu KS]]
-[[Category: Activator]]
+[[Category: Stevens RC]]
-[[Category: Developmental protein]]
-[[Category: Dna-binding]]
-[[Category: Homeobox]]
-[[Category: Homeodomain]]
-[[Category: Nanog]]
-[[Category: Nucleus]]
-[[Category: Repressor]]
-[[Category: Transcription]]
-[[Category: Transcription factor]]
-[[Category: Transcription regulation]]