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{{Seed}}
[[Image:1z3x.png|left|200px]]


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==Structure of Gun4 from Thermosynechococcus elongatus==
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<StructureSection load='1z3x' size='340' side='right'caption='[[1z3x]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1z3x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus Thermosynechococcus vestitus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3X FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_1z3x|  PDB=1z3x  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3x OCA], [https://pdbe.org/1z3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3x RCSB], [https://www.ebi.ac.uk/pdbsum/1z3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8DIJ1_THEVB Q8DIJ1_THEVB]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3x ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Gun4 has been implicated in a developmental signaling pathway between the chloroplast and the nucleus involving magnesium protoporphyrin IX (MgP(IX)), the first dedicated intermediate in the chlorophyll biosynthetic pathway. Here we present the crystal structure of Thermosynechococcus elongatus Gun4 at 1.5 A, describe the binding affinities of Gun4 for substrate and product porphyrin molecules, and identify a likely (Mg)P(IX) binding site on the protein. Kinetic analyses show that Gun4 dramatically increases the efficiency of transformation of porphyrin substrate to metalloporphyrin product and that it also reduces the threshold Mg2+ concentration required for activity at low porphyrin concentration. Gun4 therefore controls magnesium chelatase at physiologically significant Mg2+ concentrations and likely acts as a molecular switch in vivo so that in its absence magnesium chelatase is inactive. This mechanism could allow Gun4 to mediate magnesium protoporphyrin levels both for chlorophyll biosynthesis and for signaling to the nucleus.


===Structure of Gun4 from Thermosynechococcus elongatus===
Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis.,Davison PA, Schubert HL, Reid JD, Iorg CD, Heroux A, Hill CP, Hunter CN Biochemistry. 2005 May 31;44(21):7603-12. PMID:15909975<ref>PMID:15909975</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_15909975}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1z3x" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 15909975 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_15909975}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1Z3X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3X OCA].
[[Category: Thermosynechococcus vestitus]]
 
[[Category: Davison PA]]
==Reference==
[[Category: Hill CP]]
Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis., Davison PA, Schubert HL, Reid JD, Iorg CD, Heroux A, Hill CP, Hunter CN, Biochemistry. 2005 May 31;44(21):7603-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15909975 15909975]
[[Category: Hunter CN]]
[[Category: Single protein]]
[[Category: Iorg CD]]
[[Category: Thermosynechococcus elongatus]]
[[Category: Reid JD]]
[[Category: Davison, P A.]]
[[Category: Robinson H]]
[[Category: Hill, C P.]]
[[Category: Schubert HL]]
[[Category: Hunter, C N.]]
[[Category: Iorg, C D.]]
[[Category: Reid, J D.]]
[[Category: Robinson, H.]]
[[Category: Schubert, H L.]]
[[Category: Transferase activator]]
 
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