1uru: Difference between revisions

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-[[Image:1uru.png|left|200px]]
-{{STRUCTURE_1uru|  PDB=1uru  |  SCENE=  }}
+==Amphiphysin BAR domain from Drosophila==
+<StructureSection load='1uru' size='340' side='right'caption='[[1uru]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1uru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1URU FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uru OCA], [https://pdbe.org/1uru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uru RCSB], [https://www.ebi.ac.uk/pdbsum/1uru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uru ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q7KLE5_DROME Q7KLE5_DROME]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ur/1uru_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uru ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the Drosophila amphiphysin BAR domain. It is a crescent-shaped dimer that binds preferentially to highly curved negatively charged membranes. With its N-terminal amphipathic helix and BAR domain (N-BAR), amphiphysin can drive membrane curvature in vitro and in vivo. The structure is similar to that of arfaptin2, which we find also binds and tubulates membranes. From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module.
-===AMPHIPHYSIN BAR DOMAIN FROM DROSOPHILA===
+BAR domains as sensors of membrane curvature: the amphiphysin BAR structure.,Peter BJ, Kent HM, Mills IG, Vallis Y, Butler PJ, Evans PR, McMahon HT Science. 2004 Jan 23;303(5657):495-9. Epub 2003 Nov 26. PMID:14645856<ref>PMID:14645856</ref>
-{{ABSTRACT_PUBMED_14645856}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1uru" style="background-color:#fffaf0;"></div>
-[[1uru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URU OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:014645856</ref><ref group="xtra">PMID:018216767</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Drosophila melanogaster]]
-[[Category: Evans, P R.]]
+[[Category: Large Structures]]
-[[Category: Kent, H M.]]
+[[Category: Evans PR]]
-[[Category: Coiled-coil]]
+[[Category: Kent HM]]
-[[Category: Endocytosis]]
-[[Category: Membrane curvature]]