1l1s: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:1l1s.png|left|200px]]
-<!--
+==Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum==
-The line below this paragraph, containing "STRUCTURE_1l1s", creates the "Structure Box" on the page.
+<StructureSection load='1l1s' size='340' side='right'caption='[[1l1s]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1l1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1S FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_1l1s|  PDB=1l1s  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1s OCA], [https://pdbe.org/1l1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1s RCSB], [https://www.ebi.ac.uk/pdbsum/1l1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1s ProSAT], [https://www.topsan.org/Proteins/MCSG/1l1s TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/O27535_METTH O27535_METTH]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1s_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1s ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+As part of our structural proteomics initiative, we have determined the crystal structure of MTH1491, a previously uncharacterized hypothetical protein from Methanobacterium thermoautotrophicum. MTH1491 is one of numerous structural genomics targets selected in a genome-wide survey of uncharacterized proteins. It belongs to a family of proteins whose biological function is not known. The crystal structure of MTH1491, the first structure for this family of proteins, consists of an overall five-stranded parallel beta-sheet with strand order 51234 and flanking helices. The oligomeric form of this molecule is a trimer as seen from both crystal contacts and gel filtration studies. Analysis revealed that the structure of MTH1491 is similar to that of dehydrogenases, amidohydrolases, and oxidoreductases. Using a combination of sequence and structural analyses, we showed that MTH1491 does not belong to either the dehydrogenase or the amidohydrolase superfamilies of proteins.
-===Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum===
+The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.,Christendat D, Saridakis V, Kim Y, Kumar PA, Xu X, Semesi A, Joachimiak A, Arrowsmith CH, Edwards AM Protein Sci. 2002 Jun;11(6):1409-14. PMID:12021439<ref>PMID:12021439</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_12021439}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1l1s" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 12021439 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12021439}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-L1S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1S OCA].
-==Reference==
-The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum., Christendat D, Saridakis V, Kim Y, Kumar PA, Xu X, Semesi A, Joachimiak A, Arrowsmith CH, Edwards AM, Protein Sci. 2002 Jun;11(6):1409-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12021439 12021439]
 [[Category: Methanothermobacter thermautotrophicus]]
-[[Category: Single protein]]
+[[Category: Arrowsmith CH]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Christendat D]]
-[[Category: Christendat, D.]]
+[[Category: Edwards AM]]
-[[Category: Edwards, A M.]]
+[[Category: Joachimiak A]]
-[[Category: Joachimiak, A.]]
+[[Category: Kim Y]]
-[[Category: Kim, Y.]]
+[[Category: Kumar PA]]
-[[Category: Kumar, P A.]]
+[[Category: Saridakis V]]
-[[Category: MCSG, Midwest Center for Structural Genomics.]]
+[[Category: Semesi A]]
-[[Category: Saridakis, V.]]
+[[Category: Xu X]]
-[[Category: Semesi, A.]]
-[[Category: Xu, X.]]
-[[Category: Crystal structure]]
-[[Category: Hypothetical protein]]
-[[Category: Mcsg]]
-[[Category: Midwest center for structural genomic]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 11:30:43 2008''