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[[Image:1l1s.gif|left|200px]]


{{Structure
==Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum==
|PDB= 1l1s |SIZE=350|CAPTION= <scene name='initialview01'>1l1s</scene>, resolution 2.30&Aring;
<StructureSection load='1l1s' size='340' side='right'caption='[[1l1s]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
<table><tr><td colspan='2'>[[1l1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1S FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= ORF1491 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 Methanothermobacter thermautotrophicus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1416 COG1416]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1s OCA], [https://pdbe.org/1l1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1s RCSB], [https://www.ebi.ac.uk/pdbsum/1l1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1s ProSAT], [https://www.topsan.org/Proteins/MCSG/1l1s TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1s OCA], [http://www.ebi.ac.uk/pdbsum/1l1s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l1s RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/O27535_METTH O27535_METTH]
 
== Evolutionary Conservation ==
'''Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1s_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1s ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
As part of our structural proteomics initiative, we have determined the crystal structure of MTH1491, a previously uncharacterized hypothetical protein from Methanobacterium thermoautotrophicum. MTH1491 is one of numerous structural genomics targets selected in a genome-wide survey of uncharacterized proteins. It belongs to a family of proteins whose biological function is not known. The crystal structure of MTH1491, the first structure for this family of proteins, consists of an overall five-stranded parallel beta-sheet with strand order 51234 and flanking helices. The oligomeric form of this molecule is a trimer as seen from both crystal contacts and gel filtration studies. Analysis revealed that the structure of MTH1491 is similar to that of dehydrogenases, amidohydrolases, and oxidoreductases. Using a combination of sequence and structural analyses, we showed that MTH1491 does not belong to either the dehydrogenase or the amidohydrolase superfamilies of proteins.
As part of our structural proteomics initiative, we have determined the crystal structure of MTH1491, a previously uncharacterized hypothetical protein from Methanobacterium thermoautotrophicum. MTH1491 is one of numerous structural genomics targets selected in a genome-wide survey of uncharacterized proteins. It belongs to a family of proteins whose biological function is not known. The crystal structure of MTH1491, the first structure for this family of proteins, consists of an overall five-stranded parallel beta-sheet with strand order 51234 and flanking helices. The oligomeric form of this molecule is a trimer as seen from both crystal contacts and gel filtration studies. Analysis revealed that the structure of MTH1491 is similar to that of dehydrogenases, amidohydrolases, and oxidoreductases. Using a combination of sequence and structural analyses, we showed that MTH1491 does not belong to either the dehydrogenase or the amidohydrolase superfamilies of proteins.


==About this Structure==
The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.,Christendat D, Saridakis V, Kim Y, Kumar PA, Xu X, Semesi A, Joachimiak A, Arrowsmith CH, Edwards AM Protein Sci. 2002 Jun;11(6):1409-14. PMID:12021439<ref>PMID:12021439</ref>
1L1S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1S OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum., Christendat D, Saridakis V, Kim Y, Kumar PA, Xu X, Semesi A, Joachimiak A, Arrowsmith CH, Edwards AM, Protein Sci. 2002 Jun;11(6):1409-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12021439 12021439]
</div>
<div class="pdbe-citations 1l1s" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Christendat D]]
[[Category: Christendat, D.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Joachimiak A]]
[[Category: Joachimiak, A.]]
[[Category: Kim Y]]
[[Category: Kim, Y.]]
[[Category: Kumar PA]]
[[Category: Kumar, P A.]]
[[Category: Saridakis V]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Semesi A]]
[[Category: Saridakis, V.]]
[[Category: Xu X]]
[[Category: Semesi, A.]]
[[Category: Xu, X.]]
[[Category: crystal structure]]
[[Category: hypothetical protein]]
[[Category: mcsg]]
[[Category: midwest center for structural genomic]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
 
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