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[[Image:1xaf.gif|left|200px]]<br /><applet load="1xaf" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1xaf, resolution 2.01&Aring;" />
'''Crystal Structure of Protein of Unknown Function YfiH from Shigella flexneri 2a str. 2457T'''<br />


==About this Structure==
==Crystal Structure of Protein of Unknown Function YfiH from Shigella flexneri 2a str. 2457T==
1XAF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri_2a Shigella flexneri 2a] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAF OCA].  
<StructureSection load='1xaf' size='340' side='right'caption='[[1xaf]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[1xaf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri_2a_str._2457T Shigella flexneri 2a str. 2457T]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAF FirstGlance]. <br>
Crystal structure of hypothetical protein YfiH from Shigella flexneri at 2 A resolution., Kim Y, Maltseva N, Dementieva I, Collart F, Holzle D, Joachimiak A, Proteins. 2006 Jun 1;63(4):1097-101. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16498617 16498617]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
[[Category: Shigella flexneri 2a]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Single protein]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xaf OCA], [https://pdbe.org/1xaf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xaf RCSB], [https://www.ebi.ac.uk/pdbsum/1xaf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xaf ProSAT], [https://www.topsan.org/Proteins/MCSG/1xaf TOPSAN]</span></td></tr>
[[Category: Collart, F.]]
</table>
[[Category: Dementieva, I.]]
== Function ==
[[Category: Joachimiak, A.]]
[https://www.uniprot.org/uniprot/PURNU_SHIFL PURNU_SHIFL] Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.[UniProtKB:P84138]
[[Category: Kim, Y.]]
== Evolutionary Conservation ==
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Maltseva, N.]]
Check<jmol>
[[Category: ACT]]
  <jmolCheckbox>
[[Category: GOL]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xaf_consurf.spt"</scriptWhenChecked>
[[Category: ZN]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: hypothetical protein]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: mcsg]]
  </jmolCheckbox>
[[Category: midwest center for structural genomics]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xaf ConSurf].
[[Category: protein structure initiative]]
<div style="clear:both"></div>
[[Category: psi]]
__TOC__
[[Category: shigella flexneri 2a str. 2457t]]
</StructureSection>
[[Category: structural genomics]]
[[Category: Large Structures]]
[[Category: yfih]]
[[Category: Shigella flexneri 2a str. 2457T]]
 
[[Category: Collart F]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:52:44 2008''
[[Category: Dementieva I]]
[[Category: Joachimiak A]]
[[Category: Kim Y]]
[[Category: Maltseva N]]

Latest revision as of 12:43, 25 December 2024

Crystal Structure of Protein of Unknown Function YfiH from Shigella flexneri 2a str. 2457TCrystal Structure of Protein of Unknown Function YfiH from Shigella flexneri 2a str. 2457T

Structural highlights

1xaf is a 2 chain structure with sequence from Shigella flexneri 2a str. 2457T. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.01Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PURNU_SHIFL Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.[UniProtKB:P84138]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1xaf, resolution 2.01Å

Drag the structure with the mouse to rotate

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