1sq3: Difference between revisions

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-[[Image:1sq3.gif|left|200px]]
- {{Structure
+==Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus.==
-|PDB= 1sq3 |SIZE=350|CAPTION= <scene name='initialview01'>1sq3</scene>, resolution 2.70&Aring;
+<StructureSection load='1sq3' size='340' side='right'caption='[[1sq3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=FE:FE (III) ION'>FE</scene>
+<table><tr><td colspan='2'>[[1sq3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQ3 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-|GENE= Ftn ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 Archaeoglobus fulgidus DSM 4304])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sq3 OCA], [https://pdbe.org/1sq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1sq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sq3 ProSAT]</span></td></tr>
+</table>
-'''Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus.'''
+== Function ==
+[https://www.uniprot.org/uniprot/O29424_ARCFU O29424_ARCFU]
+== Evolutionary Conservation ==
-==Overview==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sq3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sq3 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 Ferritins are known as important iron storage/detoxification proteins and are widely found in living organisms. This report details the 2.1 A resolution native and 2.7 A resolution iron bound structures of the ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus, and represents the first structure of a ferritin from an archaeon, or a hyperthermophilic organism. The A. fulgidus ferritin (AfFtn) monomer has a high degree of structural similarity with archetypal ferritins from E. coli and humans, but the AfFtn quaternary structure is novel; 24 subunits assemble into a shell having tetrahedral (2-3) rather than the canonical octahedral (4-3-2) symmetry of archetypal ferritins. The difference in assembly opens four large (approximately 45 A) pores in the AfFtn shell. Two nonconservative amino acid substitutions may be critical for stabilizing the tetrahedral form.
-==About this Structure==
+Crystal structures of a tetrahedral open pore ferritin from the hyperthermophilic archaeon Archaeoglobus fulgidus.,Johnson E, Cascio D, Sawaya MR, Gingery M, Schroder I Structure. 2005 Apr;13(4):637-48. PMID:15837202<ref>PMID:15837202</ref>
-SQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_dsm_4304 Archaeoglobus fulgidus dsm 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ3 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Crystal structures of a tetrahedral open pore ferritin from the hyperthermophilic archaeon Archaeoglobus fulgidus., Johnson E, Cascio D, Sawaya MR, Gingery M, Schroder I, Structure. 2005 Apr;13(4):637-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15837202 15837202]
+</div>
-[[Category: Archaeoglobus fulgidus dsm 4304]]
+<div class="pdbe-citations 1sq3" style="background-color:#fffaf0;"></div>
-[[Category: Single protein]]
-[[Category: Cascio, D.]]
-[[Category: Johnson, E.]]
-[[Category: Michael, S.]]
-[[Category: Schroder, I.]]
-[[Category: FE]]
-[[Category: ferroxidase]]
-[[Category: four helix bundle]]
-[[Category: iron storage]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:08:14 2008''
+==See Also==
+*[[Ferritin 3D structures|Ferritin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Archaeoglobus fulgidus DSM 4304]]
+[[Category: Large Structures]]
+[[Category: Cascio D]]
+[[Category: Johnson E]]
+[[Category: Michael S]]
+[[Category: Schroder I]]