1sq3: Difference between revisions

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-[[Image:1sq3.png|left|200px]]
-{{STRUCTURE_1sq3|  PDB=1sq3  |  SCENE=  }}
+==Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus.==
+<StructureSection load='1sq3' size='340' side='right'caption='[[1sq3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1sq3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQ3 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sq3 OCA], [https://pdbe.org/1sq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1sq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sq3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/O29424_ARCFU O29424_ARCFU]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sq3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sq3 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Ferritins are known as important iron storage/detoxification proteins and are widely found in living organisms. This report details the 2.1 A resolution native and 2.7 A resolution iron bound structures of the ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus, and represents the first structure of a ferritin from an archaeon, or a hyperthermophilic organism. The A. fulgidus ferritin (AfFtn) monomer has a high degree of structural similarity with archetypal ferritins from E. coli and humans, but the AfFtn quaternary structure is novel; 24 subunits assemble into a shell having tetrahedral (2-3) rather than the canonical octahedral (4-3-2) symmetry of archetypal ferritins. The difference in assembly opens four large (approximately 45 A) pores in the AfFtn shell. Two nonconservative amino acid substitutions may be critical for stabilizing the tetrahedral form.
-===Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus.===
+Crystal structures of a tetrahedral open pore ferritin from the hyperthermophilic archaeon Archaeoglobus fulgidus.,Johnson E, Cascio D, Sawaya MR, Gingery M, Schroder I Structure. 2005 Apr;13(4):637-48. PMID:15837202<ref>PMID:15837202</ref>
-{{ABSTRACT_PUBMED_15837202}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1sq3" style="background-color:#fffaf0;"></div>
-[[1sq3]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ3 OCA].
 ==See Also==
-*[[Ferritin|Ferritin]]
+*[[Ferritin 3D structures|Ferritin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015837202</ref><references group="xtra"/>
+__TOC__
-[[Category: Archaeoglobus fulgidus]]
+</StructureSection>
-[[Category: Cascio, D.]]
+[[Category: Archaeoglobus fulgidus DSM 4304]]
-[[Category: Johnson, E.]]
+[[Category: Large Structures]]
-[[Category: Michael, S.]]
+[[Category: Cascio D]]
-[[Category: Schroder, I.]]
+[[Category: Johnson E]]
-[[Category: Ferroxidase]]
+[[Category: Michael S]]
-[[Category: Four helix bundle]]
+[[Category: Schroder I]]
-[[Category: Iron storage]]
-[[Category: Metal binding protein]]