1ru7: Difference between revisions

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-{{Seed}}
-[[Image:1ru7.png|left|200px]]
-<!--
+==1934 Human H1 Hemagglutinin==
-The line below this paragraph, containing "STRUCTURE_1ru7", creates the "Structure Box" on the page.
+<StructureSection load='1ru7' size='340' side='right'caption='[[1ru7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ru7]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RU7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ru7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ru7 OCA], [https://pdbe.org/1ru7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ru7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ru7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ru7 ProSAT]</span></td></tr>
-{{STRUCTURE_1ru7|  PDB=1ru7  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HEMA_I34A1 HEMA_I34A1] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ru7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ru7 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
-===1934 Human H1 Hemagglutinin===
+The structure and receptor binding properties of the 1918 influenza hemagglutinin.,Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886<ref>PMID:14764886</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1ru7" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_14764886}}, adds the Publication Abstract to the page
+*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 14764886 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_14764886}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-RU7 is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RU7 OCA].
+[[Category: Daniels RS]]
+[[Category: Gamblin SJ]]
-==Reference==
+[[Category: Ha Y]]
-<ref group="xtra">PMID:14764886</ref><references group="xtra"/>
+[[Category: Haire LF]]
-[[Category: Influenza a virus]]
+[[Category: Russell RJ]]
-[[Category: Daniels, R S.]]
+[[Category: Skehel JJ]]
-[[Category: Gamblin, S J.]]
+[[Category: Steinhauer DA]]
-[[Category: Ha, Y.]]
+[[Category: Stevens DJ]]
-[[Category: Haire, L F.]]
+[[Category: Vasisht N]]
-[[Category: Russell, R J.]]
+[[Category: Xiao B]]
-[[Category: Skehel, J J.]]
-[[Category: Steinhauer, D A.]]
-[[Category: Stevens, D J.]]
-[[Category: Vasisht, N.]]
-[[Category: Xiao, B.]]
-[[Category: Envelope protein]]
-[[Category: Glycoprotein]]
-[[Category: Hemagglutinin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:44:56 2009''