2pyp: Difference between revisions

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-[[Image:2pyp.jpg|left|200px]]
- {{Structure
+==PHOTOACTIVE YELLOW PROTEIN, PHOTOSTATIONARY STATE, 50% GROUND STATE, 50% BLEACHED==
-|PDB= 2pyp |SIZE=350|CAPTION= <scene name='initialview01'>2pyp</scene>, resolution 1.9&Aring;
+<StructureSection load='2pyp' size='340' side='right'caption='[[2pyp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=HC4:4&#39;-HYDROXYCINNAMIC ACID'>HC4</scene>
+<table><tr><td colspan='2'>[[2pyp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halorhodospira_halophila Halorhodospira halophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PYP FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=60F:(2~{R})-2-AZANYL-3-[(~{E})-3-(4-HYDROXYPHENYL)PROP-2-ENOYL]SULFANYL-PROPANOIC+ACID'>60F</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyp OCA], [https://pdbe.org/2pyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pyp RCSB], [https://www.ebi.ac.uk/pdbsum/2pyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyp ProSAT]</span></td></tr>
+</table>
-'''PHOTOACTIVE YELLOW PROTEIN, PHOTOSTATIONARY STATE, 50% GROUND STATE, 50% BLEACHED'''
+== Function ==
+[https://www.uniprot.org/uniprot/PYP_HALHA PYP_HALHA] Photoactive blue light protein. Probably functions as a photoreceptor for a negative phototaxis response.
+== Evolutionary Conservation ==
-==Overview==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/2pyp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pyp ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 The blue-light photoreceptor photoactive yellow protein (PYP) undergoes a self-contained light cycle. The atomic structure of the bleached signaling intermediate in the light cycle of PYP was determined by millisecond time-resolved, multiwavelength Laue crystallography and simultaneous optical spectroscopy. Light-induced trans-to-cis isomerization of the 4-hydroxycinnamyl chromophore and coupled protein rearrangements produce a new set of active-site hydrogen bonds. An arginine gateway opens, allowing solvent exposure and protonation of the chromophore's phenolic oxygen. Resulting changes in shape, hydrogen bonding, and electrostatic potential at the protein surface form a likely basis for signal transduction. The structural results suggest a general framework for the interpretation of protein photocycles.
-==About this Structure==
+Structure of a protein photocycle intermediate by millisecond time-resolved crystallography.,Genick UK, Borgstahl GE, Ng K, Ren Z, Pradervand C, Burke PM, Srajer V, Teng TY, Schildkamp W, McRee DE, Moffat K, Getzoff ED Science. 1997 Mar 7;275(5305):1471-5. PMID:9045611<ref>PMID:9045611</ref>
-PYP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Halorhodospira_halophila Halorhodospira halophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYP OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Structure of a protein photocycle intermediate by millisecond time-resolved crystallography., Genick UK, Borgstahl GE, Ng K, Ren Z, Pradervand C, Burke PM, Srajer V, Teng TY, Schildkamp W, McRee DE, Moffat K, Getzoff ED, Science. 1997 Mar 7;275(5305):1471-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9045611 9045611]
+</div>
+<div class="pdbe-citations 2pyp" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Halorhodospira halophila]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Borgstahl, G E.O.]]
+[[Category: Borgstahl GEO]]
-[[Category: Burke, P.]]
+[[Category: Burke P]]
-[[Category: Genick, U K.]]
+[[Category: Genick UK]]
-[[Category: Getzoff, E D.]]
+[[Category: Getzoff ED]]
-[[Category: Mcree, D E.]]
+[[Category: Mcree DE]]
-[[Category: Moffat, K.]]
+[[Category: Moffat K]]
-[[Category: Ng, K.]]
+[[Category: Ng K]]
-[[Category: Pradervand, C.]]
+[[Category: Pradervand C]]
-[[Category: Ren, Z.]]
+[[Category: Ren Z]]
-[[Category: Schildkamp, W.]]
+[[Category: Schildkamp W]]
-[[Category: Srajer, V.]]
+[[Category: Srajer V]]
-[[Category: Teng, T.]]
+[[Category: Teng T]]
-[[Category: HC4]]
-[[Category: chromophore]]
-[[Category: light sensor for phototaxis]]
-[[Category: photoreceptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:41:44 2008''