2fq9: Difference between revisions

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-[[Image:2fq9.png|left|200px]]
-<!--
+==Cathepsin S with nitrile inhibitor==
-The line below this paragraph, containing "STRUCTURE_2fq9", creates the "Structure Box" on the page.
+<StructureSection load='2fq9' size='340' side='right'caption='[[2fq9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2fq9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FQ9 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CRJ:N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE'>CRJ</scene></td></tr>
-{{STRUCTURE_2fq9|  PDB=2fq9  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fq9 OCA], [https://pdbe.org/2fq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fq9 RCSB], [https://www.ebi.ac.uk/pdbsum/2fq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fq9 ProSAT]</span></td></tr>
+</table>
-===Cathepsin S with nitrile inhibitor===
+== Function ==
+[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-[[2fq9]] is a 2 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQ9 OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/2fq9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fq9 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Cathepsin]]
+*[[Cathepsin 3D structures|Cathepsin 3D structures]]
-[[Category: Cathepsin S]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Somoza, J R.]]
+[[Category: Large Structures]]
-[[Category: Antigen presentation]]
+[[Category: Somoza JR]]
-[[Category: Cysteine protease]]
-[[Category: Drug design]]
-[[Category: Hydrolase]]
-[[Category: Papain]]