2bbi: Difference between revisions

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-{{Seed}}
-[[Image:2bbi.png|left|200px]]
-<!--
+==THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION==
-The line below this paragraph, containing "STRUCTURE_2bbi", creates the "Structure Box" on the page.
+<StructureSection load='2bbi' size='340' side='right'caption='[[2bbi]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2bbi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBI FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 16 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbi OCA], [https://pdbe.org/2bbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbi RCSB], [https://www.ebi.ac.uk/pdbsum/2bbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbi ProSAT]</span></td></tr>
-{{STRUCTURE_2bbi|  PDB=2bbi  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IBB1_SOYBN IBB1_SOYBN] Inhibitor of trypsin and of chymotrypsin.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbi_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bbi ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution has been determined by two-dimensional 1H nuclear magnetic resonance spectroscopy and dynamical simulated annealing using the program XPLOR. The structure was defined by 907 NOEs involving intra- and interresidue contacts which served as distance constraints for a protocol of dynamical simulated annealing. In addition, 48 phi angle constraints involving non-proline amino acids, 29 chi angle constraints, six omega angle constraints for the X-Pro peptide bond, and 35 stereoassignments for prochiral centers were incorporated during the course of the calculation. The protein is characterized by two distinct binding domains for serine protease. Each domain is comprised of a beta-hairpin (antiparallel beta-sheet and a cis-proline-containing type VIb reverse turn) with a short segment making a third strand of antiparallel beta-sheet. The structure determination and refinement are described, and the structure is compared to other structures of Bowman-Birk inhibitors as well as other families of serine protease inhibitors.
-===THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION===
+Three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution.,Werner MH, Wemmer DE Biochemistry. 1992 Feb 4;31(4):999-1010. PMID:1734975<ref>PMID:1734975</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2bbi" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_1734975}}, adds the Publication Abstract to the page
+*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 1734975 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_1734975}}
+__TOC__
+</StructureSection>
-==About this Structure==
-BBI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBI OCA].
-==Reference==
-Three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution., Werner MH, Wemmer DE, Biochemistry. 1992 Feb 4;31(4):999-1010. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1734975 1734975]
 [[Category: Glycine max]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Wemmer, D E.]]
+[[Category: Wemmer DE]]
-[[Category: Werner, M H.]]
+[[Category: Werner MH]]
-[[Category: Serine protease inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:31:32 2008''