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==Crystal structure of T-cell receptor V beta domain variant complexed with superantigen SEC3==
==Crystal structure of T-cell receptor V beta domain variant complexed with superantigen SEC3==
<StructureSection load='2aq3' size='340' side='right' caption='[[2aq3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2aq3' size='340' side='right'caption='[[2aq3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2aq3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AQ3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2aq3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AQ3 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2apb|2apb]], [[2apf|2apf]], [[2apt|2apt]], [[2apv|2apv]], [[2apw|2apw]], [[2apx|2apx]], [[2aq1|2aq1]], [[2aq2|2aq2]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">entC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aq3 OCA], [https://pdbe.org/2aq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aq3 RCSB], [https://www.ebi.ac.uk/pdbsum/2aq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aq3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aq3 OCA], [http://pdbe.org/2aq3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aq3 RCSB], [http://www.ebi.ac.uk/pdbsum/2aq3 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ENTC3_STAAU ENTC3_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/2aq3_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/2aq3_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[T-cell receptor|T-cell receptor]]
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Cho, S]]
[[Category: Mus musculus]]
[[Category: Guan, R]]
[[Category: Staphylococcus aureus]]
[[Category: Kerzic, M C]]
[[Category: Cho S]]
[[Category: Kieke, M C]]
[[Category: Guan R]]
[[Category: Kranz, D M]]
[[Category: Kerzic MC]]
[[Category: Mariuzza, R A]]
[[Category: Kieke MC]]
[[Category: Sundberg, E J]]
[[Category: Kranz DM]]
[[Category: Swaminathan, C P]]
[[Category: Mariuzza RA]]
[[Category: Yang, J]]
[[Category: Sundberg EJ]]
[[Category: Complex structure]]
[[Category: Swaminathan CP]]
[[Category: Immune system]]
[[Category: Yang J]]
[[Category: Staphlococcal enterotoxin c3]]
[[Category: T-cell receptor v beta domain]]

Latest revision as of 03:47, 21 November 2024

Crystal structure of T-cell receptor V beta domain variant complexed with superantigen SEC3Crystal structure of T-cell receptor V beta domain variant complexed with superantigen SEC3

Structural highlights

2aq3 is a 8 chain structure with sequence from Mus musculus and Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2aq3, resolution 2.30Å

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OCA
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