2aeo: Difference between revisions

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New page: left|200px<br /><applet load="2aeo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2aeo, resolution 1.80Å" /> '''Crystal structure of...
 
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[[Image:2aeo.gif|left|200px]]<br /><applet load="2aeo" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2aeo, resolution 1.80&Aring;" />
'''Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase'''<br />


==About this Structure==
==Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase==
2AEO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CU, ZN and NCP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AEO OCA].  
<StructureSection load='2aeo' size='340' side='right'caption='[[2aeo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2aeo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AEO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeo OCA], [https://pdbe.org/2aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aeo RCSB], [https://www.ebi.ac.uk/pdbsum/2aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aeo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SODC_BOVIN SODC_BOVIN] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2aeo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aeo ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Structural investigation of cisplatin-protein interactions: selective platination of His19 in a cuprozinc superoxide dismutase., Calderone V, Casini A, Mangani S, Messori L, Orioli PL, Angew Chem Int Ed Engl. 2006 Feb 13;45(8):1267-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16416478 16416478]
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Superoxide dismutase]]
[[Category: Calderone V]]
[[Category: Calderone, V.]]
[[Category: Casini A]]
[[Category: Casini, A.]]
[[Category: Mangani S]]
[[Category: Mangani, S.]]
[[Category: Messori L]]
[[Category: Messori, L.]]
[[Category: Orioli PL]]
[[Category: Orioli, P.L.]]
[[Category: CU]]
[[Category: NCP]]
[[Category: ZN]]
[[Category: cancer]]
[[Category: cisplatin]]
[[Category: cu]]
[[Category: metal based drugs]]
[[Category: platinum]]
[[Category: protein]]
[[Category: sod]]
[[Category: zn sod]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:05:04 2007''

Latest revision as of 10:48, 30 October 2024

Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutaseCrystal structure of cisplatinated bovine Cu,Zn superoxide dismutase

Structural highlights

2aeo is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SODC_BOVIN Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2aeo, resolution 1.80Å

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