1zfu: Difference between revisions

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 ==Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus==
-<StructureSection load='1zfu' size='340' side='right' caption='[[1zfu]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='1zfu' size='340' side='right'caption='[[1zfu]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebony_cup Ebony cup]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1zfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZFU FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [http://pdbe.org/1zfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [http://www.ebi.ac.uk/pdbsum/1zfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfu ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfu OCA], [https://pdbe.org/1zfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zfu RCSB], [https://www.ebi.ac.uk/pdbsum/1zfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zfu ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/DEFPL_PSENR DEFPL_PSENR] Antimicrobial peptide that potently acts against several species of Gram-positive bacteria (PubMed:16222292, PubMed:19472324). It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). It does not disrupt cell membranes (PubMed:20508130). Is especially active against numerous clinical isolates of S.pneumoniae, including all 90 different serotypes and isolates resistant to clinically used antibiotics (PubMed:16222292). In vitro, shows considerable selectivity for bacteria over mammalian cells (PubMed:16222292). The peptide synthesized in D-amino acids does not show antibacterial activity (PubMed:19472324). In vitro, acts on voltage-gated potassium channels by moderately inhibiting mammalian Kv1.3/KCNA3 (IC(50)=2.8 uM), and moderately inhibiting others potassium channels (PubMed:25568977).<ref>PMID:16222292</ref> <ref>PMID:25568977</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Ebony cup]]
+[[Category: Large Structures]]
-[[Category: Buskov, S]]
+[[Category: Pseudoplectania nigrella]]
-[[Category: Christensen, B]]
+[[Category: Buskov S]]
-[[Category: Christensen, B E]]
+[[Category: Christensen B]]
-[[Category: Elvig-Jorgensen, S G]]
+[[Category: Christensen BE]]
-[[Category: Fischer, R L]]
+[[Category: De Maria L]]
-[[Category: Frimodt-Moller, N]]
+[[Category: Elvig-Jorgensen SG]]
-[[Category: Hansen, M T]]
+[[Category: Fischer RL]]
-[[Category: Kjaerulf, S]]
+[[Category: Frimodt-Moller N]]
-[[Category: Kristensen, H H]]
+[[Category: Hansen MT]]
-[[Category: Lehrer, R I]]
+[[Category: Kjaerulf S]]
-[[Category: Ludvigsen, S]]
+[[Category: Kristensen HH]]
-[[Category: Maria, L De]]
+[[Category: Lehrer RI]]
-[[Category: Mygind, P H]]
+[[Category: Ludvigsen S]]
-[[Category: Raventos, D]]
+[[Category: Mygind PH]]
-[[Category: Schnorr, K]]
+[[Category: Raventos D]]
-[[Category: Sonksen, C P]]
+[[Category: Schnorr K]]
-[[Category: Sorensen, M V]]
+[[Category: Sonksen CP]]
-[[Category: Taboureau, O]]
+[[Category: Sorensen MV]]
-[[Category: Yaver, D]]
+[[Category: Taboureau O]]
-[[Category: Zasloff, M]]
+[[Category: Yaver D]]
-[[Category: Antimicrobial peptide]]
+[[Category: Zasloff M]]
-[[Category: Antimicrobial protein]]
-[[Category: Cysteine stabilized alpha-beta motif]]
-[[Category: Defensin]]