1xnq: Difference between revisions

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-[[Image:1xnq.png|left|200px]]
-{{STRUCTURE_1xnq|  PDB=1xnq  |  SCENE=  }}
+==Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center==
+<StructureSection load='1xnq' size='340' side='right'caption='[[1xnq]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1xnq]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XNQ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PAR:PAROMOMYCIN'>PAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xnq OCA], [https://pdbe.org/1xnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xnq RCSB], [https://www.ebi.ac.uk/pdbsum/1xnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xnq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RS2_THET8 RS2_THET8] Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xn/1xnq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xnq ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position.
-===Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center===
+Structure of a purine-purine wobble base pair in the decoding center of the ribosome.,Murphy FV 4th, Ramakrishnan V Nat Struct Mol Biol. 2004 Dec;11(12):1251-2. Epub 2004 Nov 21. PMID:15558050<ref>PMID:15558050</ref>
-{{ABSTRACT_PUBMED_15558050}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1xnq" style="background-color:#fffaf0;"></div>
-[[1xnq]] is a 23 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNQ OCA].
 ==See Also==
-*[[Ribosomal protein S10|Ribosomal protein S10]]
+*[[Ribosomal protein THX 3D structures|Ribosomal protein THX 3D structures]]
-*[[Ribosomal protein S11|Ribosomal protein S11]]
+*[[Ribosome 3D structures|Ribosome 3D structures]]
-*[[Ribosomal protein S12|Ribosomal protein S12]]
+*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
-*[[Ribosomal protein S13|Ribosomal protein S13]]
+== References ==
-*[[Ribosomal protein S14|Ribosomal protein S14]]
+<references/>
-*[[Ribosomal protein S15|Ribosomal protein S15]]
+__TOC__
-*[[Ribosomal protein S16|Ribosomal protein S16]]
+</StructureSection>
-*[[Ribosomal protein S17|Ribosomal protein S17]]
+[[Category: Large Structures]]
-*[[Ribosomal protein S18|Ribosomal protein S18]]
-*[[Ribosomal protein S19|Ribosomal protein S19]]
-*[[Ribosomal protein S2|Ribosomal protein S2]]
-*[[Ribosomal protein S20|Ribosomal protein S20]]
-*[[Ribosomal protein S3|Ribosomal protein S3]]
-*[[Ribosomal protein S4|Ribosomal protein S4]]
-*[[Ribosomal protein S5|Ribosomal protein S5]]
-*[[Ribosomal protein S6|Ribosomal protein S6]]
-*[[Ribosomal protein S7|Ribosomal protein S7]]
-*[[Ribosomal protein S8|Ribosomal protein S8]]
-*[[Ribosomal protein S9|Ribosomal protein S9]]
-*[[Ribosomal protein THX|Ribosomal protein THX]]
-==Reference==
-<ref group="xtra">PMID:015558050</ref><references group="xtra"/>
 [[Category: Thermus thermophilus]]
-[[Category: Murphy, F V.]]
+[[Category: Murphy FV]]
-[[Category: Ramakrishnan, V.]]
+[[Category: Ramakrishnan V]]
-[[Category: Decoding]]
-[[Category: Inosine]]
-[[Category: Ribosome]]
-[[Category: Translation]]