1xmw: Difference between revisions

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 ==CD3 EPSILON AND DELTA ECTODOMAIN FRAGMENT COMPLEX IN SINGLE-CHAIN CONSTRUCT==
-<StructureSection load='1xmw' size='340' side='right' caption='[[1xmw]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
+<StructureSection load='1xmw' size='340' side='right'caption='[[1xmw]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1xmw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_ammon_aries Ovis ammon aries]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XMW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1xmw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XMW FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD3E, CD3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9940 Ovis ammon aries])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xmw OCA], [http://pdbe.org/1xmw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xmw RCSB], [http://www.ebi.ac.uk/pdbsum/1xmw PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xmw OCA], [https://pdbe.org/1xmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xmw RCSB], [https://www.ebi.ac.uk/pdbsum/1xmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xmw ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CD3E_MOUSE CD3E_MOUSE]] The CD3 complex mediates signal transduction.
+[https://www.uniprot.org/uniprot/CD3D_SHEEP CD3D_SHEEP] Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.[UniProtKB:P04234][https://www.uniprot.org/uniprot/CD3E_MOUSE CD3E_MOUSE] The CD3 complex mediates signal transduction.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xmw_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xmw_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xmw ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 29: / Line 30: @@
 ==See Also==
-*[[CD3|CD3]]
+*[[CD3 3D structures|CD3 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ovis ammon aries]]
+[[Category: Large Structures]]
-[[Category: Fahmy, A]]
+[[Category: Mus musculus]]
-[[Category: Kim, I C]]
+[[Category: Ovis aries]]
-[[Category: Kim, S T]]
+[[Category: Fahmy A]]
-[[Category: Reinherz, E L]]
+[[Category: Kim IC]]
-[[Category: Sun, Z Y.J]]
+[[Category: Kim ST]]
-[[Category: Wagner, G]]
+[[Category: Reinherz EL]]
-[[Category: Beta-sheet]]
+[[Category: Sun Z-YJ]]
-[[Category: C1-set immunoglobulin superfamily]]
+[[Category: Wagner G]]
-[[Category: H-bonded g strand pair]]
-[[Category: Signaling protein]]
-[[Category: Single-chain]]