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==CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 DB AND KB MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE==
 
<StructureSection load='1wbx' size='340' side='right' caption='[[1wbx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
==CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE==
<StructureSection load='1wbx' size='340' side='right'caption='[[1wbx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wbx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WBX FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wbx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WBX FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bii|1bii]], [[1bqh|1bqh]], [[1bz9|1bz9]], [[1cd1|1cd1]], [[1ddh|1ddh]], [[1ffn|1ffn]], [[1ffo|1ffo]], [[1ffp|1ffp]], [[1fg2|1fg2]], [[1fo0|1fo0]], [[1fzj|1fzj]], [[1fzk|1fzk]], [[1fzm|1fzm]], [[1fzo|1fzo]], [[1g6r|1g6r]], [[1g7p|1g7p]], [[1g7q|1g7q]], [[1hoc|1hoc]], [[1inq|1inq]], [[1jpf|1jpf]], [[1jpg|1jpg]], [[1juf|1juf]], [[1k8d|1k8d]], [[1kbg|1kbg]], [[1kj2|1kj2]], [[1kj3|1kj3]], [[1kpu|1kpu]], [[1kpv|1kpv]], [[1l6q|1l6q]], [[1ld9|1ld9]], [[1ldp|1ldp]], [[1leg|1leg]], [[1lek|1lek]], [[1lk2|1lk2]], [[1mhc|1mhc]], [[1mwa|1mwa]], [[1n3n|1n3n]], [[1n59|1n59]], [[1n5a|1n5a]], [[1nam|1nam]], [[1nan|1nan]], [[1nez|1nez]], [[1osz|1osz]], [[1p1z|1p1z]], [[1p4l|1p4l]], [[1pqz|1pqz]], [[1qo3|1qo3]], [[1s7q|1s7q]], [[1s7r|1s7r]], [[1s7s|1s7s]], [[1s7t|1s7t]], [[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[1vac|1vac]], [[1vad|1vad]], [[2ckb|2ckb]], [[2mha|2mha]], [[2vaa|2vaa]], [[2vab|2vab]], [[1ce6|1ce6]], [[1wby|1wby]], [[1wbz|1wbz]], [[1qlf|1qlf]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wbx RCSB], [http://www.ebi.ac.uk/pdbsum/1wbx PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbx OCA], [https://pdbe.org/1wbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wbx RCSB], [https://www.ebi.ac.uk/pdbsum/1wbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wbx ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/1wbx_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/1wbx_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wbx ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1wbx" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[Major histocompatibility complex|Major histocompatibility complex]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Influenza A virus]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Lai, C.]]
[[Category: Lai C]]
[[Category: Liu, J.]]
[[Category: Liu J]]
[[Category: Meijers, R.]]
[[Category: Meijers R]]
[[Category: Reinherz, E L.]]
[[Category: Reinherz EL]]
[[Category: Wang, J.]]
[[Category: Wang J]]
[[Category: Yang, Y.]]
[[Category: Yang Y]]
[[Category: Zhong, W.]]
[[Category: Zhong W]]
[[Category: Ha468]]
[[Category: Immune system]]
[[Category: Influenza peptide]]
[[Category: Mhc class i]]

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