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[[Image:1tkf.gif|left|200px]]<br /><applet load="1tkf" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1tkf, resolution 1.20&Aring;" />
'''Streptomyces griseus aminopeptidase complexed with D-tryptophan'''<br />


==About this Structure==
==Streptomyces griseus aminopeptidase complexed with D-tryptophan==
1TKF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_chryseus Streptomyces chryseus] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=DTR:'>DTR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKF OCA].
<StructureSection load='1tkf' size='340' side='right'caption='[[1tkf]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
[[Category: Single protein]]
== Structural highlights ==
[[Category: Streptomyces chryseus]]
<table><tr><td colspan='2'>[[1tkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_griseus Streptomyces griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TKF FirstGlance]. <br>
[[Category: Blumberg, S.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
[[Category: Gilboa, R.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Reiland, V.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tkf OCA], [https://pdbe.org/1tkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tkf RCSB], [https://www.ebi.ac.uk/pdbsum/1tkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tkf ProSAT]</span></td></tr>
[[Category: Schomburg, D.]]
</table>
[[Category: Shoham, G.]]
== Function ==
[[Category: Shoham, Y.]]
[https://www.uniprot.org/uniprot/APX_STRGG APX_STRGG] An exopeptidase specific for larger hydrophobic amino acids (especially leucine), no cleavage occurs if the next residue is proline (PubMed:8444149).<ref>PMID:2503378</ref> <ref>PMID:8444149</ref> <ref>PMID:8665903</ref>
[[Category: Spungin-Bialik, A.]]
== Evolutionary Conservation ==
[[Category: CA]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: DTR]]
Check<jmol>
[[Category: ZN]]
  <jmolCheckbox>
[[Category: calcium activation]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tk/1tkf_consurf.spt"</scriptWhenChecked>
[[Category: double-zinc metalloproteinase]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: protein-inhibitor complex]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tkf ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:14:28 2008''
==See Also==
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
*[[Streptomyces griseus Aminopeptidase (SGAP)|Streptomyces griseus Aminopeptidase (SGAP)]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces griseus]]
[[Category: Blumberg S]]
[[Category: Gilboa R]]
[[Category: Reiland V]]
[[Category: Schomburg D]]
[[Category: Shoham G]]
[[Category: Shoham Y]]
[[Category: Spungin-Bialik A]]

Latest revision as of 10:28, 30 October 2024

Streptomyces griseus aminopeptidase complexed with D-tryptophanStreptomyces griseus aminopeptidase complexed with D-tryptophan

Structural highlights

1tkf is a 1 chain structure with sequence from Streptomyces griseus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

APX_STRGG An exopeptidase specific for larger hydrophobic amino acids (especially leucine), no cleavage occurs if the next residue is proline (PubMed:8444149).[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Spungin A, Blumberg S. Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme. Eur J Biochem. 1989 Aug 1;183(2):471-7. PMID:2503378 doi:10.1111/j.1432-1033.1989.tb14952.x
  2. ↑ Ben-Meir D, Spungin A, Ashkenazi R, Blumberg S. Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution. Eur J Biochem. 1993 Feb 15;212(1):107-12. PMID:8444149 doi:10.1111/j.1432-1033.1993.tb17639.x
  3. ↑ Maras B, Greenblatt HM, Shoham G, Spungin-Bialik A, Blumberg S, Barra D. Aminopeptidase from Streptomyces griseus: primary structure and comparison with other zinc-containing aminopeptidases. Eur J Biochem. 1996 Mar 15;236(3):843-6. PMID:8665903 doi:10.1111/j.1432-1033.1996.00843.x

1tkf, resolution 1.20Å

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