1tk4: Difference between revisions
New page: left|200px<br /><applet load="1tk4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tk4, resolution 1.10Å" /> '''Crystal structure of... |
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== | ==Crystal structure of russells viper phospholipase A2 in complex with a specifically designed tetrapeptide Ala-Ile-Arg-Ser at 1.1 A resolution== | ||
<StructureSection load='1tk4' size='340' side='right'caption='[[1tk4]], [[Resolution|resolution]] 1.10Å' scene=''> | |||
== Structural highlights == | |||
[ | <table><tr><td colspan='2'>[[1tk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TK4 FirstGlance]. <br> | ||
[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> | ||
[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk4 OCA], [https://pdbe.org/1tk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tk4 RCSB], [https://www.ebi.ac.uk/pdbsum/1tk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tk4 ProSAT]</span></td></tr> | ||
</table> | |||
[[ | == Function == | ||
[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref> | |||
== Evolutionary Conservation == | |||
[ | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
<jmolCheckbox> | |||
[[ | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tk/1tk4_consurf.spt"</scriptWhenChecked> | ||
[ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tk4 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Daboia russelii pulchella]] | |||
[[Category: Large Structures]] | |||
[[Category: Betzel C]] | |||
[[Category: Bilgrami S]] | |||
[[Category: Dey S]] | |||
[[Category: Kaur P]] | |||
[[Category: Perbandt M]] | |||
[[Category: Sharma S]] | |||
[[Category: Singh N]] | |||
[[Category: Singh TP]] | |||
[[Category: Somvanshi RK]] | |||
