1scy: Difference between revisions
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<StructureSection load='1scy' size='340' side='right'caption='[[1scy]]' scene=''> | <StructureSection load='1scy' size='340' side='right'caption='[[1scy]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1scy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1scy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_hebraeus Leiurus hebraeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SCY FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 25 models</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1scy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1scy OCA], [https://pdbe.org/1scy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1scy RCSB], [https://www.ebi.ac.uk/pdbsum/1scy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1scy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1scy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1scy OCA], [https://pdbe.org/1scy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1scy RCSB], [https://www.ebi.ac.uk/pdbsum/1scy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1scy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KAX51_LEIHE KAX51_LEIHE] Blocker for the small conductance calcium-activated potassium channels (PubMed: | [https://www.uniprot.org/uniprot/KAX51_LEIHE KAX51_LEIHE] Blocker for the small conductance calcium-activated potassium channels (PubMed:11527975, PubMed:2307683, PubMed:2839478). Shows the best affinity for KCa2.2/KCNN2 (Kd=0.2 nM), followed by KCa2.3/KCNN3 (Kd=1.1 nM) and KCa2.1/KCNN1 (Kd=325 nM) (PubMed:11527975).<ref>PMID:11527975</ref> <ref>PMID:2307683</ref> <ref>PMID:2839478</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Leiurus | [[Category: Leiurus hebraeus]] | ||
[[Category: Borremans FAM]] | [[Category: Borremans FAM]] | ||
[[Category: Martins JC]] | [[Category: Martins JC]] | ||
[[Category: Van De Ven FJM]] | [[Category: Van De Ven FJM]] | ||