1qnu: Difference between revisions

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-==SHIGA-LIKE TOXIN I B SUBUNIT COMPLEXED WITH THE BRIDGED-STARFISH INHIBITOR==
-<StructureSection load='1qnu' size='340' side='right' caption='[[1qnu]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
+==Shiga-Like Toxin I B Subunit Complexed with the Bridged-Starfish Inhibitor==
+<StructureSection load='1qnu' size='340' side='right'caption='[[1qnu]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1qnu]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Phage_h30 Phage h30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1qnu]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNU FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EMB:METHYL-CARBAMIC+ACID+ETHYL+ESTER'>EMB</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MEC:ETHYL-CARBAMIC+ACID+METHYL+ESTER'>MEC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qnu RCSB], [http://www.ebi.ac.uk/pdbsum/1qnu PDBsum]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EMB:METHYL-CARBAMIC+ACID+ETHYL+ESTER'>EMB</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MEC:ETHYL-CARBAMIC+ACID+METHYL+ESTER'>MEC</scene></td></tr>
-<table>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnu OCA], [https://pdbe.org/1qnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnu RCSB], [https://www.ebi.ac.uk/pdbsum/1qnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/V5URS0_9CAUD V5URS0_9CAUD] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.[ARBA:ARBA00003218]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnu_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnu_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnu ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 24: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1qnu" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Shiga toxin|Shiga toxin]]
+*[[Shiga toxin 3D structures|Shiga toxin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Phage h30]]
+[[Category: Escherichia coli O157:H7]]
-[[Category: Hayakawa, K.]]
+[[Category: Large Structures]]
-[[Category: Pannu, N S.]]
+[[Category: Hayakawa K]]
-[[Category: Read, R J.]]
+[[Category: Pannu NS]]
-[[Category: Multivalent protein-carbohydrate recognition]]
+[[Category: Read RJ]]
-[[Category: Ob-fold]]
-[[Category: Subnanomolar inhibitor]]
-[[Category: Toxin]]