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==Structural Analysis of Integrin alpha IIb beta 3- Disintegrin with the AKGDWN Motif== | ==Structural Analysis of Integrin alpha IIb beta 3- Disintegrin with the AKGDWN Motif== | ||
<StructureSection load='1q7j' size='340' side='right'caption='[[1q7j | <StructureSection load='1q7j' size='340' side='right'caption='[[1q7j]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1q7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1q7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7J FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7j OCA], [https://pdbe.org/1q7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7j RCSB], [https://www.ebi.ac.uk/pdbsum/1q7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7j ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7j OCA], [https://pdbe.org/1q7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7j RCSB], [https://www.ebi.ac.uk/pdbsum/1q7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7j ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7j_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7j_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Calloselasma rhodostoma]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Chen CY]] | ||
[[Category: Chen | [[Category: Chen YC]] | ||
[[Category: Chuang | [[Category: Chuang WJ]] | ||
[[Category: Shiu | [[Category: Shiu JH]] | ||
Latest revision as of 03:23, 21 November 2024
Structural Analysis of Integrin alpha IIb beta 3- Disintegrin with the AKGDWN MotifStructural Analysis of Integrin alpha IIb beta 3- Disintegrin with the AKGDWN Motif
Structural highlights
FunctionVM2RH_CALRH Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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