1pm1: Difference between revisions

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-[[Image:1pm1.jpg|left|200px]]
- {{Structure
+==Crystal structure of nitrophorin 2 L122V/L132V mutant complex with imidazole==
-|PDB= 1pm1 |SIZE=350|CAPTION= <scene name='initialview01'>1pm1</scene>, resolution 1.10&Aring;
+<StructureSection load='1pm1' size='340' side='right'caption='[[1pm1]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>
+<table><tr><td colspan='2'>[[1pm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PM1 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm1 OCA], [https://pdbe.org/1pm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pm1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pm1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NP2_RHOPR NP2_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).  Specifically inhibits factor IXa-catalyzed activation of factor X in the presence of calcium and phospholipids irrespective of the presence or absence of factor VIIIa.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pm/1pm1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pm1 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of nitrophorin 2 L122V/L132V mutant complex with imidazole'''
+==See Also==
+*[[Nitrophorin|Nitrophorin]]
+__TOC__
-==About this Structure==
+</StructureSection>
-PM1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM1 OCA].
+[[Category: Large Structures]]
 [[Category: Rhodnius prolixus]]
-[[Category: Single protein]]
+[[Category: Montfort WR]]
-[[Category: Montfort, W R.]]
+[[Category: Weichsel A]]
-[[Category: Weichsel, A.]]
-[[Category: HEM]]
-[[Category: IMD]]
-[[Category: beta barrel]]
-[[Category: ferric heme]]
-[[Category: imidazole]]
-[[Category: lipocalin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:26:03 2008''