1p2q: Difference between revisions

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<StructureSection load='1p2q' size='340' side='right'caption='[[1p2q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1p2q' size='340' side='right'caption='[[1p2q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin] and [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[1p2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P2Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p2i|1p2i]], [[1p2j|1p2j]], [[1p2k|1p2k]], [[1p2m|1p2m]], [[1p2n|1p2n]], [[1p2o|1p2o]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [https://pdbe.org/1p2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [https://www.ebi.ac.uk/pdbsum/1p2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p2q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p2q OCA], [https://pdbe.org/1p2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p2q RCSB], [https://www.ebi.ac.uk/pdbsum/1p2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p2q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/1p2q_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/1p2q_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Bovin]]
[[Category: Chymotrypsin]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Czapinska, H]]
[[Category: Czapinska H]]
[[Category: Helland, R]]
[[Category: Helland R]]
[[Category: Leiros, I]]
[[Category: Leiros I]]
[[Category: Olufsen, M]]
[[Category: Olufsen M]]
[[Category: Otlewski, J]]
[[Category: Otlewski J]]
[[Category: Smalaas, A O]]
[[Category: Smalaas AO]]
[[Category: Bovine pancreatic trypsin inhibitor]]
[[Category: Crystal structure]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Non-cognate binding]]
[[Category: Primary specificity]]
[[Category: Protein-protein interaction]]
[[Category: S1 pocket]]
[[Category: Serine proteinase]]
[[Category: Trypsin]]

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