1ors: Difference between revisions

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-{{Seed}}
-[[Image:1ors.png|left|200px]]
-<!--
+==X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab==
-The line below this paragraph, containing "STRUCTURE_1ors", creates the "Structure Box" on the page.
+<StructureSection load='1ors' size='340' side='right'caption='[[1ors]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ors]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORS FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ors FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ors OCA], [https://pdbe.org/1ors PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ors RCSB], [https://www.ebi.ac.uk/pdbsum/1ors PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ors ProSAT]</span></td></tr>
-{{STRUCTURE_1ors|  PDB=1ors  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1ors_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ors ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Voltage-dependent K+ channels are members of the family of voltage-dependent cation (K+, Na+ and Ca2+) channels that open and allow ion conduction in response to changes in cell membrane voltage. This form of gating underlies the generation of nerve and muscle action potentials, among other processes. Here we present the structure of KvAP, a voltage-dependent K+ channel from Aeropyrum pernix. We have determined a crystal structure of the full-length channel at a resolution of 3.2 A, and of the isolated voltage-sensor domain at 1.9 A, both in complex with monoclonal Fab fragments. The channel contains a central ion-conduction pore surrounded by voltage sensors, which form what we call 'voltage-sensor paddles'-hydrophobic, cationic, helix-turn-helix structures on the channel's outer perimeter. Flexible hinges suggest that the voltage-sensor paddles move in response to membrane voltage changes, carrying their positive charge across the membrane.
-===X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab===
+X-ray structure of a voltage-dependent K+ channel.,Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R Nature. 2003 May 1;423(6935):33-41. PMID:12721618<ref>PMID:12721618</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1ors" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_12721618}}, adds the Publication Abstract to the page
+*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 12721618 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12721618}}
+__TOC__
+</StructureSection>
-==About this Structure==
-ORS is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORS OCA].
-==Reference==
-<ref group="xtra">PMID:12721618</ref><references group="xtra"/>
 [[Category: Aeropyrum pernix]]
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Cadene, M.]]
+[[Category: Cadene M]]
-[[Category: Chait, B T.]]
+[[Category: Chait BT]]
-[[Category: Chen, J.]]
+[[Category: Chen J]]
-[[Category: Jiang, Y.]]
+[[Category: Jiang Y]]
-[[Category: Lee, A.]]
+[[Category: Lee A]]
-[[Category: MacKinnon, R.]]
+[[Category: MacKinnon R]]
-[[Category: Ruta, V.]]
+[[Category: Ruta V]]
-[[Category: Fab complex]]
-[[Category: Kvap]]
-[[Category: Potassium channel]]
-[[Category: Voltage sensor]]
-[[Category: Voltage-dependent]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:15:50 2009''