1oa5: Difference between revisions

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-[[Image:1oa5.png|left|200px]]
-<!--
+==The solution structure of bovine pancreatic trypsin inhibitor at high pressure==
-The line below this paragraph, containing "STRUCTURE_1oa5", creates the "Structure Box" on the page.
+<StructureSection load='1oa5' size='340' side='right'caption='[[1oa5]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1oa5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OA5 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 3 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oa5 OCA], [https://pdbe.org/1oa5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oa5 RCSB], [https://www.ebi.ac.uk/pdbsum/1oa5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oa5 ProSAT]</span></td></tr>
-{{STRUCTURE_1oa5|  PDB=1oa5  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oa5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oa5 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The solution structure of bovine pancreatic trypsin inhibitor (BPTI) at a pressure of 2 kbar is presented. The structure was calculated as a change from an energy-minimized low-pressure structure, using (1)H chemical shifts as restraints. The structure has changed by 0.24 A RMS, and has almost unchanged volume. The largest changes as a result of pressure are in the loop 10-16, which contains the active site of BPTI, and residues 38-42, which are adjacent to buried water molecules. Hydrogen bonds are compressed by 0.029 +/- 0.117 A, with the longer hydrogen bonds, including those to internal buried water molecules, being compressed more. The hydrophobic core is also compressed, largely from reduction of packing defects. The parts of the structure that have the greatest change are close to buried water molecules, thus highlighting the importance of water molecules as the nucleation sites for volume fluctuation of proteins in native conditions.
-===THE SOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR AT HIGH PRESSURE===
+The solution structure of bovine pancreatic trypsin inhibitor at high pressure.,Williamson MP, Akasaka K, Refaee M Protein Sci. 2003 Sep;12(9):1971-9. PMID:12930996<ref>PMID:12930996</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_12930996}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1oa5" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 12930996 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_12930996}}
-==About this Structure==
-[[1oa5]] is a 1 chain structure of [[Basic Pancreatic Trypsin Inhibitor]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OA5 OCA].
 ==See Also==
-*[[Basic Pancreatic Trypsin Inhibitor]]
+*[[BPTI 3D structures|BPTI 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:12930996</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Bos taurus]]
-[[Category: Akasaka, K.]]
+[[Category: Large Structures]]
-[[Category: Refaee, M.]]
+[[Category: Akasaka K]]
-[[Category: Williamson, M P.]]
+[[Category: Refaee M]]
-[[Category: Hydrolase inhibitor]]
+[[Category: Williamson MP]]
-[[Category: Protease inhibitor]]