1n3n: Difference between revisions

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==Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db==
==Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db==
<StructureSection load='1n3n' size='340' side='right' caption='[[1n3n]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1n3n' size='340' side='right'caption='[[1n3n]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1n3n]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N3N FirstGlance]. <br>
<table><tr><td colspan='2'>[[1n3n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N3N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3n OCA], [http://pdbe.org/1n3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n3n RCSB], [http://www.ebi.ac.uk/pdbsum/1n3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n3n ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3n OCA], [https://pdbe.org/1n3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n3n RCSB], [https://www.ebi.ac.uk/pdbsum/1n3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n3n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.  
[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/1n3n_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/1n3n_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1n3n" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1n3n" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Capitani, G]]
[[Category: Mus musculus]]
[[Category: Ciatto, C]]
[[Category: Capitani G]]
[[Category: Grutter, M G]]
[[Category: Ciatto C]]
[[Category: Pecorari, F]]
[[Category: Grutter MG]]
[[Category: Pluckthun, A]]
[[Category: Pecorari F]]
[[Category: Tissot, A C]]
[[Category: Pluckthun A]]
[[Category: Immune system]]
[[Category: Tissot AC]]
[[Category: Immunoglobulin fold]]

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