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==TM9A251-284: A Peptide Model of the C-Terminus of a Rat Striated Alpha Tropomyosin==
==TM9A251-284: A Peptide Model of the C-Terminus of a Rat Striated Alpha Tropomyosin==
<StructureSection load='1mv4' size='340' side='right'caption='[[1mv4]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1mv4' size='340' side='right'caption='[[1mv4]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1mv4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MV4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1mv4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MV4 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ihq|1ihq]], [[1tmz|1tmz]], [[1ic2|1ic2]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mv4 OCA], [https://pdbe.org/1mv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1mv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mv4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mv4 OCA], [https://pdbe.org/1mv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1mv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mv4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TPM1_RAT TPM1_RAT]] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.  
[https://www.uniprot.org/uniprot/TPM1_RAT TPM1_RAT] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mv/1mv4_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mv/1mv4_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Tropomyosin|Tropomyosin]]
*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Graboski, S]]
[[Category: Rattus norvegicus]]
[[Category: Greenfield, N J]]
[[Category: Graboski S]]
[[Category: Hitchcock-Degregori, S E]]
[[Category: Greenfield NJ]]
[[Category: Huang, Y]]
[[Category: Hitchcock-Degregori SE]]
[[Category: Montelione, G T]]
[[Category: Huang Y]]
[[Category: Palm, T]]
[[Category: Montelione GT]]
[[Category: Swapna, G V.T]]
[[Category: Palm T]]
[[Category: Actin-binding]]
[[Category: Swapna GVT]]
[[Category: Alpha-helix]]
[[Category: Coiled-coil]]
[[Category: De novo protein]]
[[Category: Dimer]]
[[Category: Disulfide cross-linked]]
[[Category: Exon 9a]]
[[Category: Muscle]]
[[Category: Peptide-model]]
[[Category: Tropomyosin]]
[[Category: Troponin binding]]
[[Category: Two-chained]]

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