1m1g: Difference between revisions

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-{{Seed}}
-[[Image:1m1g.png|left|200px]]
-<!--
+==Crystal Structure of Aquifex aeolicus N-utilization substance G (NusG), Space Group P2(1)==
-The line below this paragraph, containing "STRUCTURE_1m1g", creates the "Structure Box" on the page.
+<StructureSection load='1m1g' size='340' side='right'caption='[[1m1g]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1m1g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M1G FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1g OCA], [https://pdbe.org/1m1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m1g RCSB], [https://www.ebi.ac.uk/pdbsum/1m1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m1g ProSAT]</span></td></tr>
-{{STRUCTURE_1m1g|  PDB=1m1g  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NUSG_AQUAE NUSG_AQUAE] Influences transcription termination and antitermination. Acts as a component of the transcription complex, and interacts with the termination factor rho and RNA polymerase (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m1g_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m1g ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Microbial transcription modulator NusG interacts with RNA polymerase and termination factor rho, displaying striking functional homology to eukaryotic Spt5. The protein is also a translational regulator. We have determined crystal structures of Aquifex aeolicus NusG showing a modular design: an N-terminal RNP-like domain, a C-terminal element with a KOW sequence motif and a species-specific immunoglobulin-like fold. The structures reveal bona fide nucleic acid binding sites, and nucleic acid binding activities can be detected for NusG from three organisms and for the KOW element alone. A conserved KOW domain is defined as a new class of nucleic acid binding folds. This module is a close structural homolog of tudor protein-protein interaction motifs. Putative protein binding sites for the RNP and KOW domains can be deduced, which differ from the areas implicated in nucleic acid interactions. The results strongly argue that both protein and nucleic acid contacts are important for NusG's functions and that the factor can act as an adaptor mediating indirect protein-nucleic acid associations.
-===Crystal Structure of Aquifex aeolicus N-utilization substance G (NusG), Space Group P2(1)===
+Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities.,Steiner T, Kaiser JT, Marinkovic S, Huber R, Wahl MC EMBO J. 2002 Sep 2;21(17):4641-53. PMID:12198166<ref>PMID:12198166</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_12198166}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1m1g" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 12198166 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12198166}}
+__TOC__
+</StructureSection>
-==About this Structure==
-M1G is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1G OCA].
-==Reference==
-<ref group="xtra">PMID:12198166</ref><references group="xtra"/>
 [[Category: Aquifex aeolicus]]
-[[Category: Huber, R.]]
+[[Category: Large Structures]]
-[[Category: Kaiser, J T.]]
+[[Category: Huber R]]
-[[Category: Marinkovic, S.]]
+[[Category: Kaiser JT]]
-[[Category: Steiner, T.]]
+[[Category: Marinkovic S]]
-[[Category: Wahl, M C.]]
+[[Category: Steiner T]]
-[[Category: Antitermination]]
+[[Category: Wahl MC]]
-[[Category: Immunoglobulin fold]]
-[[Category: Kow domain]]
-[[Category: Nucleic acid interaction]]
-[[Category: Protein-protein interaction]]
-[[Category: Rnp motif]]
-[[Category: Transcription termination]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:13:57 2009''