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==SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1==
==SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1==
<StructureSection load='1l1m' size='340' side='right' caption='[[1l1m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1l1m' size='340' side='right'caption='[[1l1m]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1l1m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1M FirstGlance]. <br>
<table><tr><td colspan='2'>[[1l1m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1M FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LACI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1m OCA], [http://pdbe.org/1l1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l1m RCSB], [http://www.ebi.ac.uk/pdbsum/1l1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1m OCA], [https://pdbe.org/1l1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1m RCSB], [https://www.ebi.ac.uk/pdbsum/1l1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI]] Repressor of the lactose operon. Binds allolactose as an inducer.  
[https://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI] Repressor of the lactose operon. Binds allolactose as an inducer.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1m_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1m_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Lac repressor morph methods|Lac repressor morph methods]]
*[[Lac repressor|Lac repressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Boelens, R]]
[[Category: Large Structures]]
[[Category: Bonvin, A M.J J]]
[[Category: Boelens R]]
[[Category: Kalodimos, C G]]
[[Category: Bonvin AMJJ]]
[[Category: Kaptein, R]]
[[Category: Kalodimos CG]]
[[Category: Salinas, R K]]
[[Category: Kaptein R]]
[[Category: Wechselberger, R]]
[[Category: Salinas RK]]
[[Category: Asymmetric dna-binding]]
[[Category: Wechselberger R]]
[[Category: Hth]]
[[Category: Lac operon]]
[[Category: Lac repressor]]
[[Category: Natural lac operator]]
[[Category: Transcription regulation]]
[[Category: Transcription regulator-dna complex]]

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