3ncm: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{STRUCTURE_3ncm|  PDB=3ncm  |  SCENE=  }}
-===NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES===
-{{ABSTRACT_PUBMED_10331878}}
-==About this Structure==
+==NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES==
-[[3ncm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA].
+<StructureSection load='3ncm' size='340' side='right'caption='[[3ncm]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ncm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NCM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ncm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ncm OCA], [https://pdbe.org/3ncm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ncm RCSB], [https://www.ebi.ac.uk/pdbsum/3ncm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ncm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NCAM1_MOUSE NCAM1_MOUSE] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/3ncm_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ncm ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.
-==Reference==
+Structure and interactions of NCAM modules 1 and 2, basic elements in neural cell adhesion.,Jensen PH, Soroka V, Thomsen NK, Ralets I, Berezin V, Bock E, Poulsen FM Nat Struct Biol. 1999 May;6(5):486-93. PMID:10331878<ref>PMID:10331878</ref>
-<ref group="xtra">PMID:010331878</ref><references group="xtra"/><references/>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3ncm" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Berezin, V.]]
+[[Category: Berezin V]]
-[[Category: Bock, E.]]
+[[Category: Bock E]]
-[[Category: Jensen, P H.]]
+[[Category: Jensen PH]]
-[[Category: Poulsen, F M.]]
+[[Category: Poulsen FM]]
-[[Category: Soroka, V.]]
+[[Category: Soroka V]]
-[[Category: Thomsen, N K.]]
+[[Category: Thomsen NK]]
-[[Category: Cell adhesion]]
-[[Category: Cell adhesion protein]]
-[[Category: Glycoprotein]]
-[[Category: Gpi-anchor]]
-[[Category: Heparin-binding]]
-[[Category: Homophilic binding]]
-[[Category: Immunoglobulin fold]]
-[[Category: Neural adhesion molecule]]