3ldh: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(17 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:3ldh.gif|left|200px]]


{{Structure
==A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes==
|PDB= 3ldh |SIZE=350|CAPTION= <scene name='initialview01'>3ldh</scene>, resolution 3.0&Aring;
<StructureSection load='3ldh' size='340' side='right'caption='[[3ldh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>
<table><tr><td colspan='2'>[[3ldh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Squalus_acanthias Squalus acanthias]. The June 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Lactate Dehydrogenase''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_6 10.2210/rcsb_pdb/mom_2008_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDH FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldh OCA], [https://pdbe.org/3ldh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldh RCSB], [https://www.ebi.ac.uk/pdbsum/3ldh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldh ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ldh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldh OCA], [http://www.ebi.ac.uk/pdbsum/3ldh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3ldh RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/LDHA_SQUAC LDHA_SQUAC]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/3ldh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ldh ConSurf].
<div style="clear:both"></div>


'''A COMPARISON OF THE STRUCTURES OF APO DOGFISH M4 LACTATE DEHYDROGENASE AND ITS TERNARY COMPLEXES'''
==See Also==
 
*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3LDH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDH OCA].
[[Category: Lactate Dehydrogenase]]
 
[[Category: Large Structures]]
==Reference==
[[Category: RCSB PDB Molecule of the Month]]
A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes., White JL, Hackert ML, Buehner M, Adams MJ, Ford GC, Lentz PJ Jr, Smiley IE, Steindel SJ, Rossmann MG, J Mol Biol. 1976 Apr 25;102(4):759-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/940154 940154]
[[Category: Squalus acanthias]]
[[Category: L-lactate dehydrogenase]]
[[Category: Adams MJ]]
[[Category: Single protein]]
[[Category: Buehner M]]
[[Category: Adams, M J.]]
[[Category: Ford GC]]
[[Category: Buehner, M.]]
[[Category: Hackert ML]]
[[Category: Ford, G C.]]
[[Category: Lentzjunior PJ]]
[[Category: Hackert, M L.]]
[[Category: Rossmann MG]]
[[Category: Lentzjunior, P J.]]
[[Category: Smiley IE]]
[[Category: Rossmann, M G.]]
[[Category: Steindel SJ]]
[[Category: Smiley, I E.]]
[[Category: White JL]]
[[Category: Steindel, S J.]]
[[Category: White, J L.]]
[[Category: choh donor]]
[[Category: nad acceptr]]
[[Category: oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:34:18 2008''

Latest revision as of 12:23, 30 October 2024

A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexesA comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes

Structural highlights

3ldh is a 1 chain structure with sequence from Squalus acanthias. The June 2008 RCSB PDB Molecule of the Month feature on Lactate Dehydrogenase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2008_6. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LDHA_SQUAC

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ldh, resolution 3.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3ldh&oldid=4199337"