1inc: Difference between revisions

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-[[Image:1inc.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURES OF THE COMPLEX OF PORCINE PANCREATIC ELASTASE WITH TWO VALINE-DERIVED BENZOXAZINONE INHIBITORS==
-The line below this paragraph, containing "STRUCTURE_1inc", creates the "Structure Box" on the page.
+<StructureSection load='1inc' size='340' side='right'caption='[[1inc]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1inc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa_domesticus Sus scrofa domesticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1INC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1INC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ICL:[1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC+ACID+TERT-BUTYL+ESTER'>ICL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1inc|  PDB=1inc  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1inc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1inc OCA], [https://pdbe.org/1inc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1inc RCSB], [https://www.ebi.ac.uk/pdbsum/1inc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1inc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/1inc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1inc ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structures of porcine pancreatic elastase complexed to two similar benzoxazinone inhibitors are reported to 2.09 A and 1.76 A resolution, and refined to conventional R factors of 0.153 and 0.172.
-===CRYSTAL STRUCTURES OF THE COMPLEX OF PORCINE PANCREATIC ELASTASE WITH TWO VALINE-DERIVED BENZOXAZINONE INHIBITORS===
+Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors.,Radhakrishnan R, Presta LG, Meyer EF Jr, Wildonger R J Mol Biol. 1987 Dec 5;198(3):417-24. PMID:3430613<ref>PMID:3430613</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_3430613}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1inc" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 3430613 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_3430613}}
-==About this Structure==
-[[1inc]] is a 1 chain structure of [[Elastase]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa_domestica Sus scrofa domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1INC OCA].
 ==See Also==
-*[[Elastase]]
+*[[Elastase 3D structures|Elastase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:3430613</ref><references group="xtra"/>
+__TOC__
-[[Category: Pancreatic elastase]]
+</StructureSection>
-[[Category: Sus scrofa domestica]]
+[[Category: Large Structures]]
-[[Category: Meyer, E.]]
+[[Category: Sus scrofa domesticus]]
+[[Category: Meyer E]]