1hpw: Difference between revisions

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-{{Seed}}
-[[Image:1hpw.png|left|200px]]
-<!--
+==STRUCTURE OF A PILIN MONOMER FROM PSEUDOMONAS AERUGINOSA: IMPLICATIONS FOR THE ASSEMBLY OF PILI.==
-The line below this paragraph, containing "STRUCTURE_1hpw", creates the "Structure Box" on the page.
+<StructureSection load='1hpw' size='340' side='right'caption='[[1hpw]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1hpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HPW FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hpw OCA], [https://pdbe.org/1hpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hpw RCSB], [https://www.ebi.ac.uk/pdbsum/1hpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hpw ProSAT]</span></td></tr>
-{{STRUCTURE_1hpw|  PDB=1hpw  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FMP1_PSEAI FMP1_PSEAI]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/1hpw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hpw ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Type IV pilin monomers assemble to form fibers called pili that are required for a variety of bacterial functions. Pilin monomers oligomerize due to the interaction of part of their hydrophobic N-terminal alpha-helix. Engineering of a truncated pilin from Pseudomonas aeruginosa strain K122-4, where the first 28 residues are removed from the N terminus, yields a soluble, monomeric protein. This truncated pilin is shown to bind to its receptor and to decrease morbidity and mortality in mice upon administration 15 min before challenge with a heterologous strain of Pseudomonas. The structure of this truncated pilin reveals an alpha-helix at the N terminus that lies across a 4-stranded antiparallel beta-sheet. A model for a pilus is proposed that takes into account both electrostatic and hydrophobic interactions of pilin subunits as well as previously published x-ray fiber diffraction data. Our model indicates that DNA or RNA cannot pass through the center of the pilus, however, the possibility exists for small organic molecules to pass through indicating a potential mechanism for signal transduction.
-===STRUCTURE OF A PILIN MONOMER FROM PSEUDOMONAS AERUGINOSA: IMPLICATIONS FOR THE ASSEMBLY OF PILI.===
+Structure of a pilin monomer from Pseudomonas aeruginosa: implications for the assembly of pili.,Keizer DW, Slupsky CM, Kalisiak M, Campbell AP, Crump MP, Sastry PA, Hazes B, Irvin RT, Sykes BD J Biol Chem. 2001 Jun 29;276(26):24186-93. Epub 2001 Apr 9. PMID:11294863<ref>PMID:11294863</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1hpw" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_11294863}}, adds the Publication Abstract to the page
+*[[Pilin 3D structures|Pilin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 11294863 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_11294863}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-HPW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HPW OCA].
-==Reference==
-Structure of a pilin monomer from Pseudomonas aeruginosa: implications for the assembly of pili., Keizer DW, Slupsky CM, Kalisiak M, Campbell AP, Crump MP, Sastry PA, Hazes B, Irvin RT, Sykes BD, J Biol Chem. 2001 Jun 29;276(26):24186-93. Epub 2001 Apr 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11294863 11294863]
 [[Category: Pseudomonas aeruginosa]]
-[[Category: Single protein]]
+[[Category: Campbell AP]]
-[[Category: Campbell, A P.]]
+[[Category: Irvin RT]]
-[[Category: Irvin, R T.]]
+[[Category: Keizer DW]]
-[[Category: Keizer, D W.]]
+[[Category: Slupsky CM]]
-[[Category: Slupsky, C M.]]
+[[Category: Sykes BD]]
-[[Category: Sykes, B D.]]
-[[Category: Fimbria]]
-[[Category: Methylation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:30:54 2008''