1hp9: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==kappa-Hefutoxins: a novel Class of Potassium Channel Toxins from Scorpion venom==
-<StructureSection load='1hp9' size='340' side='right' caption='[[1hp9]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='1hp9' size='340' side='right'caption='[[1hp9]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1hp9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HP9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1hp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chersonesometrus_fulvipes Chersonesometrus fulvipes]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HP9 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hp9 RCSB], [http://www.ebi.ac.uk/pdbsum/1hp9 PDBsum]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp9 OCA], [https://pdbe.org/1hp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hp9 RCSB], [https://www.ebi.ac.uk/pdbsum/1hp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hp9 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/KKX11_CHEFU KKX11_CHEFU] Shows weak blocking activity on voltage-gated potassium channels Kv10.1/KCNH1/EAG1 (IC(50)=26 uM), Kv1.2/KCNA2 (Kd=150 uM), Kv1.3/KCNA3 (Kd=40 uM), Kv1.6/KCNA3 (16.6% inhibition at 40 uM toxin) (PubMed:12034709, PubMed:23726856, PubMed:27578329). The block is dose-dependent, voltage-independent, and reversible (PubMed:12034709). Also shows a weak inhibitory activity on the plant pathogen F.culmorum growth (IC(50)=18.8-37.7 uM) (PubMed:27578329).<ref>PMID:12034709</ref> <ref>PMID:23726856</ref> <ref>PMID:27578329</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 13: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1hp9" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Potassium channel toxin|Potassium channel toxin]]
+*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Bowie, J H]]
+[[Category: Chersonesometrus fulvipes]]
-[[Category: Cheng, B]]
+[[Category: Large Structures]]
-[[Category: Chia, C S.Brian]]
+[[Category: Bowie JH]]
-[[Category: Gopalakrishnakone, P]]
+[[Category: Brian Chia CS]]
-[[Category: Huys, I]]
+[[Category: Cheng B]]
-[[Category: Kini, R M]]
+[[Category: Gopalakrishnakone P]]
-[[Category: Kumar, T K.S]]
+[[Category: Huys I]]
-[[Category: Ranganathan, S]]
+[[Category: Kini RM]]
-[[Category: Sasaki, T]]
+[[Category: Kumar TKS]]
-[[Category: Sato, K]]
+[[Category: Ranganathan S]]
-[[Category: Sivaraja, V]]
+[[Category: Sasaki T]]
-[[Category: Srinivasan, K N]]
+[[Category: Sato K]]
-[[Category: Tytgat, J]]
+[[Category: Sivaraja V]]
-[[Category: Yu, C]]
+[[Category: Srinivasan KN]]
-[[Category: Gating modifier]]
+[[Category: Tytgat J]]
-[[Category: Scorpion toxin]]
+[[Category: Yu C]]
-[[Category: Toxin]]
-[[Category: Voltage-gated potassium channel]]