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==STRUCTURE OF STREPTOCOCCAL PYROGENIC EXOTOXIN A==
==STRUCTURE OF STREPTOCOCCAL PYROGENIC EXOTOXIN A==
<StructureSection load='1fnv' size='340' side='right' caption='[[1fnv]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<StructureSection load='1fnv' size='340' side='right'caption='[[1fnv]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1fnv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_phage_t12 Streptococcus phage t12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FNV FirstGlance]. <br>
<table><tr><td colspan='2'>[[1fnv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_phage_T12 Streptococcus phage T12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fnu|1fnu]], [[1fnw|1fnw]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnv OCA], [http://pdbe.org/1fnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fnv RCSB], [http://www.ebi.ac.uk/pdbsum/1fnv PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnv OCA], [https://pdbe.org/1fnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnv RCSB], [https://www.ebi.ac.uk/pdbsum/1fnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY]] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.  
[https://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnv_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnv_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnv ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
*[[Exotoxin|Exotoxin]]
*[[Exotoxin 3D structures|Exotoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptococcus phage t12]]
[[Category: Large Structures]]
[[Category: Earhart, C A]]
[[Category: Streptococcus phage T12]]
[[Category: Ohlendorf, D H]]
[[Category: Earhart CA]]
[[Category: Roggiani, M]]
[[Category: Ohlendorf DH]]
[[Category: Schlievert, P M]]
[[Category: Roggiani M]]
[[Category: Vath, G M]]
[[Category: Schlievert PM]]
[[Category: Exotoxin some]]
[[Category: Vath GM]]
[[Category: Superantigen]]
[[Category: Toxin]]

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