1ewo: Difference between revisions

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-[[Image:1ewo.png|left|200px]]
-{{STRUCTURE_1ewo|  PDB=1ewo  |  SCENE=  }}
+==THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204==
+<StructureSection load='1ewo' size='340' side='right'caption='[[1ewo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-===THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ewo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EWO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VSC:N-[N-BENZYLOXYCARBONYL-PHENYLALANINYL]-3-AMINO-5-PHENYL-PENTANE-1-SULFONIC+ACID+PHENYL+ESTER'>VSC</scene></td></tr>
-[[1ewo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWO OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ewo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewo OCA], [https://pdbe.org/1ewo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ewo RCSB], [https://www.ebi.ac.uk/pdbsum/1ewo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ewo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.  The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ewo ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Cruzain|Cruzain]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Trypanosoma cruzi]]
-[[Category: Brinen, L S.]]
+[[Category: Brinen LS]]
-[[Category: Fletterick, R J.]]
+[[Category: Fletterick RJ]]
-[[Category: Gillmor, S A.]]
+[[Category: Gillmor SA]]
-[[Category: Covalent inhibitor]]
-[[Category: Cruzipain]]
-[[Category: Cysteine protease]]
-[[Category: Drug design]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]