1dg2: Difference between revisions

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-{{Seed}}
-[[Image:1dg2.png|left|200px]]
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+==SOLUTION CONFORMATION OF A-CONOTOXIN AUIB==
-The line below this paragraph, containing "STRUCTURE_1dg2", creates the "Structure Box" on the page.
+<StructureSection load='1dg2' size='340' side='right'caption='[[1dg2]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1dg2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_aulicus Conus aulicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DG2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-{{STRUCTURE_1dg2|  PDB=1dg2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg2 OCA], [https://pdbe.org/1dg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dg2 RCSB], [https://www.ebi.ac.uk/pdbsum/1dg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dg2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CA1B_CONAL CA1B_CONAL] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian nAChR alpha-3/beta-4 subunits.<ref>PMID:9786965</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The neuronal nicotinic acetylcholine receptors constitute a highly diverse group, with subtypes consisting of pentameric combinations of alpha and beta subunits. alpha-Conotoxins are a homologous series of small peptides that antagonize these receptors. We present the three-dimensional solution structure of alpha-conotoxin AuIB, the first 15-residue alpha-conotoxin known to selectively block the alpha(3)beta(4) nicotinic acetylcholine receptor subtype. The pairwise backbone and heavy-atom root mean square deviation for an ensemble of 20 structures are 0.269 and 0.720 A, respectively. The overall fold of alpha-conotoxin AuIB closely resembles that of the alpha4/7 subfamily alpha-conotoxins. However, the absence of Tyr(15), normally present in other alpha4/7 members, results in tight bending of the backbone at the C terminus and effectively renders Asp(14) to assume the spatial location of Tyr(15) present in other neuronal alpha4/7 alpha-conotoxins. Structural comparison of alpha-conotoxin AuIB with the alpha(3)beta(2) subtype-specific alpha-conotoxin MII shows different electrostatic surface charge distributions, which may be important in differential receptor subtype recognition.
-===SOLUTION CONFORMATION OF A-CONOTOXIN AUIB===
+Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist.,Cho JH, Mok KH, Olivera BM, McIntosh JM, Park KH, Han KH J Biol Chem. 2000 Mar 24;275(12):8680-5. PMID:10722709<ref>PMID:10722709</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_10722709}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1dg2" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 10722709 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_10722709}}
+__TOC__
+</StructureSection>
-==About this Structure==
-DG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_aulicus Conus aulicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG2 OCA].
-==Reference==
-Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist., Cho JH, Mok KH, Olivera BM, McIntosh JM, Park KH, Han KH, J Biol Chem. 2000 Mar 24;275(12):8680-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10722709 10722709]
 [[Category: Conus aulicus]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Cho, J H.]]
+[[Category: Cho J-H]]
-[[Category: Han, K H.]]
+[[Category: Han K-H]]
-[[Category: McIntosh, J M.]]
+[[Category: McIntosh JM]]
-[[Category: Mok, K H.]]
+[[Category: Mok KH]]
-[[Category: Olivera, B M.]]
+[[Category: Olivera BM]]
-[[Category: Park, K H.]]
+[[Category: Park K-H]]
-[[Category: A-helix]]
-[[Category: Two disulfide bonds and c-term amidation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:01:36 2008''