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==SOLUTION CONFORMATION OF A-CONOTOXIN AUIB==
==SOLUTION CONFORMATION OF A-CONOTOXIN AUIB==
<StructureSection load='1dg2' size='340' side='right' caption='[[1dg2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1dg2' size='340' side='right'caption='[[1dg2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1dg2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_aulicus Conus aulicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DG2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1dg2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_aulicus Conus aulicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DG2 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg2 OCA], [http://pdbe.org/1dg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dg2 RCSB], [http://www.ebi.ac.uk/pdbsum/1dg2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dg2 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg2 OCA], [https://pdbe.org/1dg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dg2 RCSB], [https://www.ebi.ac.uk/pdbsum/1dg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dg2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CA1B_CONAL CA1B_CONAL]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian nAChR alpha-3/beta-4 subunits.<ref>PMID:9786965</ref>
[https://www.uniprot.org/uniprot/CA1B_CONAL CA1B_CONAL] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian nAChR alpha-3/beta-4 subunits.<ref>PMID:9786965</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Conus aulicus]]
[[Category: Conus aulicus]]
[[Category: Cho, J H]]
[[Category: Large Structures]]
[[Category: Han, K H]]
[[Category: Cho J-H]]
[[Category: McIntosh, J M]]
[[Category: Han K-H]]
[[Category: Mok, K H]]
[[Category: McIntosh JM]]
[[Category: Olivera, B M]]
[[Category: Mok KH]]
[[Category: Park, K H]]
[[Category: Olivera BM]]
[[Category: A-helix]]
[[Category: Park K-H]]
[[Category: Toxin]]
[[Category: Two disulfide bonds and c-term amidation]]

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