1b9t: Difference between revisions

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 ==NOVEL AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE MAKE SELECTIVE INTERACTIONS WITH CONSERVED RESIDUES AND WATER MOLECULES IN THE ACTIVE SITE==
-<StructureSection load='1b9t' size='340' side='right' caption='[[1b9t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='1b9t' size='340' side='right'caption='[[1b9t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1b9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/lee/40) Influenza b virus (b/lee/40)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9T FirstGlance]. <br>
+<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B9T FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RAI:1-(4-CARBOXY-2-GUANIDINOPENTYL)-5,5-DI(HYDROXYMETHYL)PYRROLIDIN-2-ONE'>RAI</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RAI:1-(4-CARBOXY-2-GUANIDINOPENTYL)-5,5-DI(HYDROXYMETHYL)PYRROLIDIN-2-ONE'>RAI</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9t RCSB], [http://www.ebi.ac.uk/pdbsum/1b9t PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9t OCA], [https://pdbe.org/1b9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b9t RCSB], [https://www.ebi.ac.uk/pdbsum/1b9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b9t ProSAT]</span></td></tr>
 </table>
-== Function ==
-[[http://www.uniprot.org/uniprot/NRAM_INBLE NRAM_INBLE]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 16: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1b9t" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Neuraminidase|Neuraminidase]]
+*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Exo-alpha-sialidase]]
+[[Category: Large Structures]]
-[[Category: Air, G M]]
+[[Category: Air GM]]
-[[Category: Atigadda, V R]]
+[[Category: Atigadda VR]]
-[[Category: Brouillette, W J]]
+[[Category: Brouillette WJ]]
-[[Category: Duarte, F]]
+[[Category: Duarte F]]
-[[Category: Finley, J B]]
+[[Category: Finley JB]]
-[[Category: Luo, M]]
+[[Category: Luo M]]
-[[Category: Zhao, J J]]
+[[Category: Zhao JJ]]
-[[Category: B/lee/40]]
-[[Category: Hydrolase]]
-[[Category: Influenza]]
-[[Category: Inhibitor]]
-[[Category: Neuraminidase]]
-[[Category: Sialidase]]