1aqb: Difference between revisions

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-{{Seed}}
-[[Image:1aqb.png|left|200px]]
-<!--
+==RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA==
-The line below this paragraph, containing "STRUCTURE_1aqb", creates the "Structure Box" on the page.
+<StructureSection load='1aqb' size='340' side='right'caption='[[1aqb]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1aqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa_domesticus Sus scrofa domesticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQB FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
-{{STRUCTURE_1aqb|  PDB=1aqb  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqb OCA], [https://pdbe.org/1aqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqb RCSB], [https://www.ebi.ac.uk/pdbsum/1aqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RET4_PIG RET4_PIG] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqb ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structure of pig plasma retinol-binding protein (RBP) has been determined at 1.65 A resolution. The space group is P212121, with a = 45.81 (4), b = 53.14 (5), c = 72.97 (8) A and one protein molecule in the asymmetric unit. The structure has been solved using the molecular replacement method and refined with restrained least squares to an R factor of 0.1844 and an Rfree of 0.237 for 18 874 and 1001 independent reflections, respectively. The relatively high resolution structure of pig holoRBP has revealed some new structural details. Moreover, it has provided a description of the binding site for Cd2+, a metal ion which is required for protein crystallization. The hepta-coordination of the RBP-bound cadmium ion involves different residues of two symmetry-related RBP molecules, consistent with the participation of the cation in intermolecular interactions that in turn promote protein crystallization.
-===RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA===
+Structure of pig plasma retinol-binding protein at 1.65 A resolution.,Zanotti G, Panzalorto M, Marcato A, Malpeli G, Folli C, Berni R Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1049-52. PMID:9757135<ref>PMID:9757135</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1aqb" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_9757135}}, adds the Publication Abstract to the page
+*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 9757135 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_9757135}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-AQB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa_domestica Sus scrofa domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQB OCA].
+[[Category: Sus scrofa domesticus]]
+[[Category: Berni R]]
-==Reference==
+[[Category: Folli C]]
-<ref group="xtra">PMID:9757135</ref><references group="xtra"/>
+[[Category: Malpeli G]]
-[[Category: Sus scrofa domestica]]
+[[Category: Marcato A]]
-[[Category: Berni, R.]]
+[[Category: Panzalorto M]]
-[[Category: Folli, C.]]
+[[Category: Zanotti G]]
-[[Category: Malpeli, G.]]
-[[Category: Marcato, A.]]
-[[Category: Panzalorto, M.]]
-[[Category: Zanotti, G.]]
-[[Category: Cadmium ion]]
-[[Category: Retinoid]]
-[[Category: Retinol transport]]
-[[Category: Vitamin some]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:56:58 2009''