1aft: Difference between revisions

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OCA

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-[[Image:1aft.gif|left|200px]]<br /><applet load="1aft" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1aft" />
-'''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES'''<br />
-==Overview==
+==SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES==
-The structure of peptide N-AcYTLDADF when bound to the large subunit of, mouse ribonucleotide reductase has been elucidated by transfer NOE. This, structure suggests a general design for type 1 RR inhibitors.
+<StructureSection load='1aft' size='340' side='right'caption='[[1aft]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1aft]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AFT FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 26 models</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aft OCA], [https://pdbe.org/1aft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aft RCSB], [https://www.ebi.ac.uk/pdbsum/1aft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aft ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RIR2_MOUSE RIR2_MOUSE] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.
-==About this Structure==
+NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.,Fisher A, Laub PB, Cooperman BS Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667<ref>PMID:7583667</ref>
-AFT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit., Fisher A, Laub PB, Cooperman BS, Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7583667 7583667]
+</div>
-[[Category: Ribonucleoside-diphosphate reductase]]
+<div class="pdbe-citations 1aft" style="background-color:#fffaf0;"></div>
-[[Category: Single protein]]
+== References ==
-[[Category: Barwis, B.A.]]
+<references/>
-[[Category: Cooperman, B.S.]]
+__TOC__
-[[Category: Fisher, A.L.]]
+</StructureSection>
-[[Category: Furst, G.T.]]
+[[Category: Large Structures]]
-[[Category: Hamann, C.S.]]
+[[Category: Barwis BA]]
-[[Category: Laub, P.B.]]
+[[Category: Cooperman BS]]
-[[Category: ACE]]
+[[Category: Fisher AL]]
-[[Category: nonstandard type i turn]]
+[[Category: Furst GT]]
-[[Category: peptide inhibitors]]
+[[Category: Hamann CS]]
-[[Category: restrained molecular dynamics]]
+[[Category: Laub PB]]
-[[Category: ribonucleotide reductase]]
-[[Category: transferred noesy]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:49:18 2007''