1aft: Difference between revisions

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[[Image:1aft.gif|left|200px]]


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==SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES==
The line below this paragraph, containing "STRUCTURE_1aft", creates the "Structure Box" on the page.
<StructureSection load='1aft' size='340' side='right'caption='[[1aft]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1aft]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AFT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 26 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
{{STRUCTURE_1aft|  PDB=1aft  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aft OCA], [https://pdbe.org/1aft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aft RCSB], [https://www.ebi.ac.uk/pdbsum/1aft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aft ProSAT]</span></td></tr>
 
</table>
'''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES'''
== Function ==
 
[https://www.uniprot.org/uniprot/RIR2_MOUSE RIR2_MOUSE] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity).
 
<div style="background-color:#fffaf0;">
==Overview==
== Publication Abstract from PubMed ==
The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.
The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.


==About this Structure==
NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.,Fisher A, Laub PB, Cooperman BS Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667<ref>PMID:7583667</ref>
1AFT is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit., Fisher A, Laub PB, Cooperman BS, Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583667 7583667]
</div>
[[Category: Ribonucleoside-diphosphate reductase]]
<div class="pdbe-citations 1aft" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
== References ==
[[Category: Barwis, B A.]]
<references/>
[[Category: Cooperman, B S.]]
__TOC__
[[Category: Fisher, A L.]]
</StructureSection>
[[Category: Furst, G T.]]
[[Category: Large Structures]]
[[Category: Hamann, C S.]]
[[Category: Barwis BA]]
[[Category: Laub, P B.]]
[[Category: Cooperman BS]]
[[Category: Nonstandard type i turn]]
[[Category: Fisher AL]]
[[Category: Peptide inhibitor]]
[[Category: Furst GT]]
[[Category: Restrained molecular dynamic]]
[[Category: Hamann CS]]
[[Category: Ribonucleotide reductase]]
[[Category: Laub PB]]
[[Category: Transferred noesy]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:12:42 2008''

Latest revision as of 09:22, 30 October 2024

SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURESSMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES

Structural highlights

1aft is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 26 models
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RIR2_MOUSE Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity).

Publication Abstract from PubMed

The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.

NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.,Fisher A, Laub PB, Cooperman BS Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Fisher A, Laub PB, Cooperman BS. NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit. Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667
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