1opg: Difference between revisions

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-{{Seed}}
-[[Image:1opg.png|left|200px]]
-<!--
+==OPG2 FAB FRAGMENT==
-The line below this paragraph, containing "STRUCTURE_1opg", creates the "Structure Box" on the page.
+<StructureSection load='1opg' size='340' side='right'caption='[[1opg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1opg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OPG FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1opg OCA], [https://pdbe.org/1opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1opg RCSB], [https://www.ebi.ac.uk/pdbsum/1opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1opg ProSAT]</span></td></tr>
-{{STRUCTURE_1opg|  PDB=1opg  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IGHG1_MOUSE IGHG1_MOUSE]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1opg_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1opg ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Cell surface receptors called integrins mediate diverse cell adhesion phenomena through recognition of the sequence arginine-glycine-aspartic acid (RGD) present in proteins such as fibronectin and fibrinogen. Platelet aggregation in hemostasis is mediated by the binding of fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the heavy chain. The RYD loop and side chains are ordered in the 2.0-A resolution crystal structure of the Fab fragment from this antireceptor antibody. Moreover, the RYD loop assumes two clearly defined conformations that may correspond to the orientations of the loop in the free state or bound to integrin. This molecule will serve as a tool for understanding protein-integrin recognition in platelet aggregation and other RGD-mediated cell adhesion interactions.
-===OPG2 FAB FRAGMENT===
+Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site.,Kodandapani R, Veerapandian B, Kunicki TJ, Ely KR J Biol Chem. 1995 Feb 3;270(5):2268-73. PMID:7836460<ref>PMID:7836460</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1opg" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_7836460}}, adds the Publication Abstract to the page
+*[[Antibody 3D structures|Antibody 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 7836460 is the PubMed ID number.
+*[[Sandbox 20009|Sandbox 20009]]
--->
+*[[3D structures of human antibody|3D structures of human antibody]]
-{{ABSTRACT_PUBMED_7836460}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-OPG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:7836460</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Ely, K R.]]
+[[Category: Large Structures]]
-[[Category: Kodandapani, R.]]
+[[Category: Ely KR]]
-[[Category: Veerapandian, B.]]
+[[Category: Kodandapani R]]
-[[Category: Cell adhesion molecule]]
+[[Category: Veerapandian B]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:35:44 2009''