1f8t: Difference between revisions

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==FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE==
==FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE==
<StructureSection load='1f8t' size='340' side='right' caption='[[1f8t]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1f8t' size='340' side='right'caption='[[1f8t]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1f8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F8T FirstGlance]. <br>
<table><tr><td colspan='2'>[[1f8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F8T FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8t OCA], [http://pdbe.org/1f8t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f8t RCSB], [http://www.ebi.ac.uk/pdbsum/1f8t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1f8t ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8t OCA], [https://pdbe.org/1f8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f8t RCSB], [https://www.ebi.ac.uk/pdbsum/1f8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f8t ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8t_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8t_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Afonin, P V]]
[[Category: Afonin PV]]
[[Category: Fokin, A V]]
[[Category: Fokin AV]]
[[Category: Mareeva, T I]]
[[Category: Mareeva TI]]
[[Category: Mikhailova, I I]]
[[Category: Mikhailova II]]
[[Category: Tsygannik, I N]]
[[Category: Tsygannik IN]]
[[Category: Antigen-binding fragment]]
[[Category: Crystal]]
[[Category: Immune system]]
[[Category: Interleukin-2]]
[[Category: Monoclonal antibody]]
[[Category: X-ray analysis]]

Latest revision as of 02:57, 21 November 2024

FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTUREFAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE

Structural highlights

1f8t is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.

[Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms],Fokin AV, Afonin PV, Mikhailova IIu, Tsygannik IN, Mareeva TIu, Nesmeianov VA, Pangborn W, Lee N, Duax W, Siszak E, Pletnev VZ Bioorg Khim. 2000 Aug;26(8):571-8. PMID:11040993[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Fokin AV, Afonin PV, Mikhailova IIu, Tsygannik IN, Mareeva TIu, Nesmeianov VA, Pangborn W, Lee N, Duax W, Siszak E, Pletnev VZ. [Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms] Bioorg Khim. 2000 Aug;26(8):571-8. PMID:11040993

1f8t, resolution 2.20Å

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