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==COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY==
==COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY==
<StructureSection load='1b2w' size='340' side='right' caption='[[1b2w]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='1b2w' size='340' side='right'caption='[[1b2w]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1b2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B2W FirstGlance]. <br>
<table><tr><td colspan='2'>[[1b2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B2W FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b2w OCA], [http://pdbe.org/1b2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b2w RCSB], [http://www.ebi.ac.uk/pdbsum/1b2w PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b2w OCA], [https://pdbe.org/1b2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b2w RCSB], [https://www.ebi.ac.uk/pdbsum/1b2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b2w ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/1b2w_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/1b2w_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b2w ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
*[[Antibody|Antibody]]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Sandbox 20009|Sandbox 20009]]
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Homo sapiens]]
[[Category: Co, M S]]
[[Category: Large Structures]]
[[Category: Edmundson, A B]]
[[Category: Mus musculus]]
[[Category: Fan, Z]]
[[Category: Co MS]]
[[Category: Goldsteen, B Z]]
[[Category: Edmundson AB]]
[[Category: Guddat, L W]]
[[Category: Fan Z]]
[[Category: Landolfi, N F]]
[[Category: Goldsteen BZ]]
[[Category: Queen, C]]
[[Category: Guddat LW]]
[[Category: Ramsland, P A]]
[[Category: Landolfi NF]]
[[Category: Shan, L]]
[[Category: Queen C]]
[[Category: Thakur, A]]
[[Category: Ramsland PA]]
[[Category: Vasquez, M]]
[[Category: Shan L]]
[[Category: Antibody engineering]]
[[Category: Thakur A]]
[[Category: Fab]]
[[Category: Vasquez M]]
[[Category: Gamma-interferon]]
[[Category: Humanized and chimeric antibody]]
[[Category: Immune system]]
[[Category: Three-dimensional strycture]]

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