2yy2: Difference between revisions

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OCA

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-[[Image:2yy2.gif|left|200px]]<br /><applet load="2yy2" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2yy2, resolution 2.80&Aring;" />
-'''Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX'''<br />
-==About this Structure==
+==Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX==
-YY2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=IBM:'>IBM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YY2 OCA].
+<StructureSection load='2yy2' size='340' side='right'caption='[[2yy2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2yy2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YY2 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yy2 OCA], [https://pdbe.org/2yy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yy2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yy2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yy/2yy2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yy2 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Handa, N.]]
+[[Category: Handa N]]
-[[Category: Kotera, J.]]
+[[Category: Kotera J]]
-[[Category: Omori, K.]]
+[[Category: Omori K]]
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+[[Category: Shirouzu M]]
-[[Category: Shirouzu, M.]]
+[[Category: Terada T]]
-[[Category: Terada, T.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: IBM]]
-[[Category: MG]]
-[[Category: ZN]]
-[[Category: catalytic domain]]
-[[Category: hydrolase]]
-[[Category: national project on protein structural and functional analyses]]
-[[Category: nppsfa]]
-[[Category: phosphodiesterase]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomics]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:39:37 2008''