2oaz: Difference between revisions

<table><tr><td colspan='2'>[[2oaz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAZ FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=I96:N-(2-ISOPROPYLPHENYL)-3-[(2-THIENYLMETHYL)THIO]-1H-1,2,4-TRIAZOL-5-AMINE'>I96</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oaz OCA], [https://pdbe.org/2oaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oaz RCSB], [https://www.ebi.ac.uk/pdbsum/2oaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oaz ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MAP2_HUMAN MAP2_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

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[[Category: Fisher PW]]

[[Category: Hofmann GA]]

[[Category: Janson CA]]

[[Category: Johnson RK]]

[[Category: Kirkpatrick R]]

[[Category: Ma C]]

[[Category: Marino Jr JP]]

[[Category: Mattern M]]

[[Category: Meek TD]]

[[Category: Ryan D]]

[[Category: Schulz C]]

[[Category: Smith WW]]

[[Category: Tew DG]]

[[Category: Thompson SK]]

[[Category: Tomazek Jr TA]]

[[Category: Veber DF]]

[[Category: Xiong WC]]

[[Category: Yamamoto Y]]

[[Category: Yamashita K]]

[[Category: Yang G]]